Registration Dossier
Registration Dossier
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EC number: 203-702-7 | CAS number: 109-76-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1962
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data are given
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-finding toxicity Data List VI
- Author:
- Smyth, H.F. et al.
- Year:
- 1 962
- Bibliographic source:
- Am. Ind. Hyg. Assoc. J. 23, 95-107
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Trimethylenediamine
- EC Number:
- 203-702-7
- EC Name:
- Trimethylenediamine
- Cas Number:
- 109-76-2
- Molecular formula:
- C3H10N2
- IUPAC Name:
- propane-1,3-diamine
- Test material form:
- solid: crystalline
- Details on test material:
- - Name of test material: 1,3-Propanediamaine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Carworth-Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 4 - 5 weeks
- Weight at study initiation: 90 - 120 grams
- Fasting period before study: no
- Rockland rat diet
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Doses:
- The dosages were arranged in a logarithmic series differing by a factor of two.
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- 14-day post observation period
- Statistics:
- Based upon mortalities during a 14-day observation period, the most probable LD50 value and its fiducial range are estimated by the method of Thompson* using the tables of Weil**.
*Thompson, W. R.: Use of Moving Averages and Interpolation to Estimate Median Effective Dose. Bacteriol. Rev. 11: 115 (June 1947).
**Weil, C. S.: Tables for Convenient Calculation of median-Effective Dose (LD50 or ED50) and Instruction in Their Use. Biometrics 8: 249 (Sep 1952)
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 311 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 196 - <= 507
- Mortality:
- Only LD 50 value of 0.35 mL/kg bw (corr. to 311 mg/kg bw) was reported
- Clinical signs:
- other: no data
- Gross pathology:
- no data
- Other findings:
- no data
Any other information on results incl. tables
Details of toxic effects not reported other than lethal dose value. Result in publication is given as 0.35 mL/kg. Density used by the registrant for conversion: 0.89 g/mL
Applicant's summary and conclusion
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