1H-Benzimidazole-7-carboxylic acid, 2-ethoxy-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-

Toxicity to aquatic algae and cyanobacteria

Link to relevant study record(s)

Reference

Endpoint:

toxicity to aquatic algae and cyanobacteria

Remarks:

growth inhibition test

Type of information:

experimental study

Adequacy of study:

other information

Study period:

December 2007.

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study without detailed documentation

Remarks:

OECD 201

Qualifier:

according to guideline

Guideline:

OECD Guideline 201 (Alga, Growth Inhibition Test)

GLP compliance:

not specified

Test organisms (species):

Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)

Duration:

72 h

Dose descriptor:

EC50

Remarks:

yield

Effect conc.:

56 mg/L

Duration:

72 h

Dose descriptor:

NOEC

Remarks:

yield

Effect conc.:

32 mg/L

Duration:

72 h

Dose descriptor:

LOEC

Remarks:

yield

Effect conc.:

56 mg/L

Duration:

72 h

Dose descriptor:

NOEC

Remarks:

growth rate

Effect conc.:

32 mg/L

Duration:

72 h

Dose descriptor:

LOEC

Remarks:

growth rate

Effect conc.:

56 mg/L

Duration:

72 h

Dose descriptor:

EC50

Remarks:

growth rate

Effect conc.:

> 56 mg/L

Validity criteria fulfilled:

not specified

Conclusions:

The substance has a NOEC (72h) equal to 32 mg/L, for both yield and growth rate.

Description of key information

Based on the OECD 201 (growth inhibition test) on Pseudokirchinella subcapitata, the substance has a NOEC (72h) equal to 32 mg/L, for both yield and growth rate.

Key value for chemical safety assessment

EC50 for freshwater algae:

56 mg/L

EC10 or NOEC for freshwater algae:

32 mg/L