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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Remarks:
Type of genotoxicity: gene mutation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP and Guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1984

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
other: Safepharm Standard Test Method M26
Qualifier:
equivalent or similar to guideline
Guideline:
other: Method of Ames et. al.
GLP compliance:
yes
Type of assay:
bacterial reverse mutation assay

Test material

Constituent 1
Chemical structure
Reference substance name:
1,1'-binaphthyl-8,8'-dicarboxylic acid
EC Number:
249-922-7
EC Name:
1,1'-binaphthyl-8,8'-dicarboxylic acid
Cas Number:
29878-91-9
Molecular formula:
C22H14O4
IUPAC Name:
[1,1'-binaphthalene]-8,8'-dicarboxylic acid

Method

Species / strain
Species / strain / cell type:
S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
Metabolic activation:
with and without
Metabolic activation system:
S-9 Liver microson mix
Test concentrations with justification for top dose:
20-12,500 µg/plate
Vehicle / solvent:
DMSO

Results and discussion

Test results
Species / strain:
S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
Metabolic activation:
with and without
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
cytotoxicity
Remarks:
at dose levels of 2,500-12,500 µg/Plate toxicity was observed, resulting in a kill of the background lawn.
Vehicle controls validity:
valid
Remarks on result:
other: all strains/cell types tested
Remarks:
Migrated from field 'Test system'.

Applicant's summary and conclusion

Conclusions:
The test substance was found to be not mutagenic in the AMES-Test