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Environmental fate & pathways

Hydrolysis

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Reference
Endpoint:
hydrolysis
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
experimental data of read across substances
Justification for type of information:
Data for the target chemical is summarized based on the structurally similar read across chemicals
Reason / purpose:
read-across source
Reason / purpose:
read-across source
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
WoE report is based on three hydrolysis studies as-
2. and 3.
GLP compliance:
not specified
Radiolabelling:
not specified
Analytical monitoring:
not specified
Duration:
5 d
Temp.:
50 °C
Remarks:
2. The study was performed at pH 4.0, 7.0 and 9.0, respectively.
Remarks:
3. Details not known
Positive controls:
not specified
Negative controls:
not specified
Transformation products:
not specified
Temp.:
50 °C
DT50:
> 1 yr
Remarks on result:
other: 2. The study was performed at pH 4.0, 7.0 and 9.0, respectively.
DT50:
1.1 d
Remarks on result:
other: 3. Other details not known
Details on results:
2. Percentage degradation of test chemical was determined to be 3.91%, 1.085% and 4.78% at pH 4.0, 7.0 and 9.0 & at a temperature of 50°C, respectively. Since the chemical is not degradable less than 10 % in this test condition, It is presumably stable in water.
3. The half-life of test chemical is much longer in stagnant waters or groundwaters due to limited volatilization, aerobic biodegradation and photochemical decomposition. Under field conditions, in running water, the half-life of test chemical was estimated to be 1.1 days.
Validity criteria fulfilled:
not specified
Conclusions:
On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 1.1 days to > 1 yr, at pH range 4-9 and at a temperature of 50°C or 1.1 days, respectively. Thus, based on this half-life value, it can be concluded that the test chemical undergoes slow to negligible hydrolysis in water.
Executive summary:

Data available for the test chemical has been reviewed to determine the half-life of hydrolysis as a function of pH. The studies are as mentioned below:

The half-life of the test chemical was determined.The study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH). Percentage degradation of test chemical was determined to be 3.91%, 1.085% and 4.78% at pH 4.0, 7.0 and 9.0 & at a temperature of 50°C, respectively and the half-life value of test chemical was determined to be > 1 yr. Since the chemical is not degradable less than 10 % in this test condition, it is presumably stable in water.Thus based on this, test chemical is considered to be stable in water.

In an another study the half-life value of test chemical was determined to be 1.1 days. Thus based on the value, test chemical is considered to undergo slow hydrolysis in water.

On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 1.1 days to  > 1 yr, at pH range 4-9 and at a temperature of 50°C or 1.1 days, respectively. Thus, based on this half-life value, it can be concluded that the test chemical undergoes slow to negligible hydrolysis in water.

Description of key information

On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 1.1 days to > 1 yr, at pH range 4-9 and at a temperature of 50°C or 1.1 days, respectively. Thus, based on this half-life value, it can be concluded that the test chemical undergoes slow to negligible hydrolysis in water.

Key value for chemical safety assessment

Additional information

Data available for the test chemical has been reviewed to determine the half-life of hydrolysis as a function of pH. The studies are as mentioned below:

 

The half-life of the test chemical was determined. The study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH). Percentage degradation of test chemical was determined to be 3.91%, 1.085% and 4.78% at pH 4.0, 7.0 and 9.0 & at a temperature of 50°C, respectively and the half-life value of test chemical was determined to be > 1 yr. Since the chemical is not degradable less than 10 % in this test condition, it is presumably stable in water. Thus based on this, test chemical is considered to be stable in water.

 

In an another study the half-life value of test chemical was determined to be 1.1 days. Thus based on the value, test chemical is considered to undergo slow hydrolysis in water.

 

On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 1.1 days to  > 1 yr, at pH range 4-9 and at a temperature of 50°C or 1.1 days, respectively. Thus, based on this half-life value, it can be concluded that the test chemical undergoes slow to negligible hydrolysis in water.