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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Hydrolysis

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from HSDB and PubChem authoritative database
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Determination of base catalyzed second order hydrolysis rate constant and half-life of test chemical.
GLP compliance:
not specified
Radiolabelling:
not specified
Analytical monitoring:
not specified
Estimation method (if used):
Structure estimation method
Remarks:
The study was performed at pH 7.0 and 8.0, respectively.
Positive controls:
not specified
Negative controls:
not specified
Transformation products:
not specified
Key result
pH:
7
DT50:
1 yr
Type:
second order
Remarks on result:
other: Hydrolysis rate constant of test chemical was determined to be 0.21 L/mol-sec
Key result
pH:
8
DT50:
37 d
Type:
second order
Remarks on result:
other: Hydrolysis rate constant of test chemical was determined to be 0.21 L/mol-sec
Validity criteria fulfilled:
not specified
Conclusions:
The second order hydrolysis rate constant of test chemical was determined to be 0.21 L/mol-sec with a corresponding half-lives of 1.0 yrs and 37 days at pH 7 and 8, respectively.
Executive summary:

The half-life and base catalyzed second order hydrolysis rate constant was determined using a structure estimation method of the test chemical. The second order hydrolysis rate constant of test chemical was determined to be 0.21L/mol-sec with a corresponding half-lives of 1.0 yrs and 37 days at pH 7 and 8, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.

Description of key information

The half-life and base catalyzed second order hydrolysis rate constant was determined using a structure estimation method of the test chemical (authoritative databases, 2017). The second order hydrolysis rate constant of test chemical was determined to be 0.21L/mol-sec with a corresponding half-lives of 1.0 yrs and 37 days at pH 7 and 8, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.

Key value for chemical safety assessment

Half-life for hydrolysis:
1 yr

Additional information

Experimental study and predicted data of the test chemical were reviewed for the hydrolysis end point which are summarized as below:

 

In an experimental key study from authoritative databases (2017),the half-life and base catalyzed second order hydrolysis rate constant was determined using a structure estimation method of the test chemical. The second order hydrolysis rate constant of test chemical was determined to be 0.21L/mol-sec with a corresponding half-lives of 1.0 yrs and 37 days at pH 7 and 8, respectively.

 

For the test chemical, HYDROWIN v2.00 program of Estimation Programs Interface (2018) prediction model was used to predict the hydrolysis half-life of test chemical. The estimated half-life of test chemical was evaluated to be 1.024 yrs at pH 7.0 and 37.401 days at pH 8.0 (at 25ᵒC) respectively.

 

On the basis of the above results of test chemical(fromauthoritative and modelling databases,2017), it can be concluded that the hydrolysis half-life value of test chemicalranges from 37 days to 1 yr (at pH 8.0 and 7.0), respectively, indicating that the test chemical is not hydrolysable in water.

 

Waiver statement

Hydrolysis endpoint can also be considered for waiver as per in accordance with column 2 of Annex VIII of the REACH regulation, testing for this endpoint is scientifically not necessary and does not need to be conducted since the test chemical is readily biodegradable.