Registration Dossier
Registration Dossier
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EC number: 216-133-4 | CAS number: 1506-02-1
Neurotoxicity
Administrative data
Description of key information
AHTN does not show neurotoxicity as shown by neuropathological examination of brain, spinal cord, and peripheral nerves.
The EU Risk Assessment Report discussed the neurotoxic potency of AHTN. The report referenced to two subchronic dermal studies that were primarily designed to screen for possible neurotoxicity, because another closely related synthetic musk, Acetyl Ethyl Tetramethyl Tetralin (AETT), appeared to be neurotoxic. Therefore, special neuropathological examination of brain, spinal cord, and peripheral nerves was included for 2 animals per dose group and AETT was included as a positive control.
According to theEU Risk Assessment Report, in these studies, AHTN (Tonalid) was administered to 5 female rats (CRL: COBS CD) in ethanol via the intraperitoneal route at a dose of 36 mg/kg bw/day for a period of 4 days. The purpose of this study was to determine if AHTN caused blue coloration similar to acetyl ethyl tetramethyl tetralin (AETT) a polycyclic musk identified as a neurotoxic ingredient and which induced blue coloration to the internal organs of dosed animals. AHTN did not induce blue coloration of the internal organs in the treated animals. Clear evidence of neurotoxicity, both clinically and pathologically, was seen with the positive control but no such evidence for AHTN was seen in either study at any dose level.
Source:EU Risk Assessment AHTN, European Chemicals Bureau, May 2008
Key value for chemical safety assessment
Effect on neurotoxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Effect on neurotoxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Effect on neurotoxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Based on the available information classification for neurotoxicity is not warranted in accordance with EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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