2-methylbutan-1-ol

Exposure related observations in humans: other data

Administrative data

Endpoint:

exposure-related observations in humans: other data

Type of information:

migrated information: read-across based on grouping of substances (category approach)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Acceptable publication which meets basic scientific principles For justification of read across please refer to section 13.

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Sensory response to certain industrial solvent vapors

Author:

Nelson KW et al.

Year:

1943

Bibliographic source:

J . ind. Hrg. Toxicol. 25, 282

Reference 2

Reference Type:

secondary source

Title:

Fragrance raw materials monographs - Isoamyl alcohol

Author:

Opdyke DLJ

Year:

1978

Bibliographic source:

Food Chem. Tox. 16, S1, 785-788

Reference 3

Reference Type:

secondary source

Title:

No information

Author:

Rowe and McCollister

Year:

1982

Bibliographic source:

Patty's Ind. Hyg. Toxicol., 3rd ed., vol 2, page 2658

Materials and methods

Type of study / information:

Inhalation study

Endpoint addressed:

respiratory irritation

Test guideline

Qualifier:

no guideline available

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

3-methylbutan-1-ol

EC Number:

204-633-5

EC Name:

3-methylbutan-1-ol

Cas Number:

123-51-3

Molecular formula:

C5H12O

IUPAC Name:

3-methylbutan-1-ol

Details on test material:

- Name of test material (as cited in study report): Isoamyl alcohol
- Analytical purity: no data

Method

Ethical approval:

not specified

Details on study design:

The procedure followed in this study consisted of the exposure of an average number of ten persons, of mixed sexes, to a given concentration of solvent vapour for a period of 3 to 5 min, in a 1200 cubic foot gas cabinet.
After the exposure, each individual classified the effect of the vapour on the eyes, nose, and throat. The classifications were: no reaction, slightly irritating, and very irritating.
The odor was listed as absent, definite, moderate, strong, or overpowering.
Finally, each person was asked if he believed he could work in the atmosphere for an eight-hour day.

Exposure assessment:

not specified

Details on exposure:

TYPE OF EXPOSURE: inhalation

EXPOSURE LEVELS: 100 - 150 ppm (corresponding to approx. 0.366 - 0.549 mg/L)

EXPOSURE PERIOD: 3 - 5 min

Results and discussion

Results:

Irritating to the throat at 100 ppm (equivalent to approx. 0.366 mg/L) and to the eyes and nose at 150 ppm (equivalent to approx. 0.549 mg/L).
The highest concentration which the majority of subjects estimated as acceptable for an 8-hour exposure was < 100 ppm (equivalent to approx. 0.366 mg/L).