3,4-dihydro-2H-pyran

Water solubility

Administrative data

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2012

Report date:

2012

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Test material

Test material information

Constituent 1

Reference substance name:

3,4-dihydro-2H-pyran

EC Number:

203-810-4

EC Name:

3,4-dihydro-2H-pyran

Cas Number:

110-87-2

Molecular formula:

C5H8O

IUPAC Name:

3,4-dihydro-2H-pyran

Test material form:

liquid

Specific details on test material used for the study:

- Name of test material (as cited in study report): 3,4-Dihydro-2H-pyrane
- Analytical purity: 99.3 %
- Lot/batch No.: 61460397G0

Results and discussion

Water solubility

Key result

Water solubility:

7.7 g/L

Temp.:

20 °C

pH:

4.9

Details on results:

The water solubility of the test item is 7.7 ± 0.1 g/L at T = 20.0 °C ± 0.5 °C.

Any other information on results incl. tables

Individual Results

Sample	mtest item [g]	vwater [ml]	pH		ctest item single values [g/l]	ctest item mean [g/l]
Water used			6.0
1 / 24 h	7.52	45	4.8		7.06 7.01	7.04
2 / 48 h	7.51	45	4.8		7.58 7.57	7.58
3 / 72 h	7.51	45	4.8		7.78 7.70	7.74
Mean of allsingle values ± std. dev.				7.66 g/l ± 0.10 g/l

As the results increased from 24 h over 48 h to 72 h, additional samples with stirring times of 96 h and 120 h were carried out. The results of these samples (96 h: 5.5 g/L, 120 h: 6.0 g/L) were not considered, because they were significantly lower than the results of the shorter stirring times. The decrease of the values is presumably caused due to instability at long stirring times at 30°C. lnstability of the test item in water was confirmed by repeated analysis of the samples 1/24 h and 2/48 h after storage for 7 days at room temperature. The amounts of these samples showed decreases to 5.6 g/L and 5.1 g/L, respectively. The results of the sample 24 h was not considered, because the saturation concentration was obviously not reached within the stirring time of 24 h.