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Registration Dossier
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EC number: 206-190-3 | CAS number: 306-83-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Additional information
1,1-dichloro-2,2,2 -trifluoroethane (HCFC 123) is a colourless volatile liquid with a faint ethereal odour.
A melting point of -107°C and a boiling point of 28.7 °C under standard conditions are reported in a reliable handbook (Kirk-Othmer Encyclopedia of Chemical technology, 1991). A saturated liquid density ranging from 1481.2 kg/m3to 1456 kg/m3 was determined by Maezawa et al. (1990) in the temperature interval of 290-300 K under atmospheric pressure.
A vapour pressure of 934.56 hPa was measured at about 25 °C by Goodwin et al. (1992) by means of an ebulliometric method.
A Log Kow of 2.17 was estimated via the QSAR model KOWWIN v1.67 (US EPA, 2009).
Solubility in water was estimated to be >2100 mg/l by Horvat et al., (1999) by analysing two independent experimental sets.
Based on its structure, HCFC 123 is s not expected to be surface active.
In accordance with column 2 of REACH Annex X and/or with column 1 of REACH Annex IX and/or the REACH guidance on information requirements and chemical safety assessment (chapter R7.A), data on the particle size distribution, explosiveness, oxidising properties, pyrophoric properties and flammability in contact with water are not needed.
HCFC 123 has no flammable range and does not have to be classified as flammable in accordance with EU Classification, Labeling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008. As the substance is a liquid with a flash point >200°C, the data on auto flammability are not required in accordance with Column 2 of REACH Annex VII.
In accordance with column 2 of REACH Annex VII the study on explosive properties does not need to be conducted as there are no chemical groups associated with explosive properties present in this substance. In addition according to REACH guidance on information requirements and chemical safety assessment, methods are only applicable for liquids and solids.
Regarding oxidizing properties, in accordance with column 2 of REACH Annex VII, the study does not need to be conducted as the substance does not contain oxygen or halogen atoms chemically bonded to nitrogen or oxygen
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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