Registration Dossier
Registration Dossier
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EC number: 206-190-3 | CAS number: 306-83-2
Neurotoxicity
Administrative data
- Endpoint:
- neurotoxicity: sub-chronic inhalation
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 424 (Neurotoxicity Study in Rodents)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2,2-dichloro-1,1,1-trifluoroethane
- EC Number:
- 206-190-3
- EC Name:
- 2,2-dichloro-1,1,1-trifluoroethane
- Cas Number:
- 306-83-2
- Molecular formula:
- C2HCl2F3
- IUPAC Name:
- 2,2-dichloro-1,1,1-trifluoroethane
- Details on test material:
- - Name of test material (as cited in study report): Ethane,2,2-dichloro-1,1,1-trifluoro-, HCFC-123
- Purity: 99.86-99.95%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: gas
- Vehicle:
- unchanged (no vehicle)
- Analytical verification of doses or concentrations:
- yes
- Duration of treatment / exposure:
- 13-week, 6 hours/day, 5 days/week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
300, 1000, 5000
Basis:
nominal conc.
- No. of animals per sex per dose:
- 10
- Control animals:
- yes, concurrent no treatment
Results and discussion
Any other information on results incl. tables
There were no treatment-related effects at any time or exposure level on the brain weight or on any of the nerve tissues. There was no apparent specific clinical sign although the body weight gain was slightly reduced in the high concentration group. The Irwin behavioural screen showed no treatment-related change, except for an apparent tendency to a reduction in arousal in male rats, which attained statistical significance at 1,000 and 5,000 ppm on week 13. It should be noted that the behavioural assessment was performed on the day after the last 6-h exposure. By that time, the rats should normally have recovered from the anaesthesia-like effects that occurred during the inhalation exposure of HCFC-123 at concentrations of 5,000 ppm and above. However, the arousal reduction might be interpreted as a residual effect in animals that may have not fully recovered from the anaesthesia-like effects of the previous day.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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