Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 206-190-3 | CAS number: 306-83-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Reference Type:
- publication
- Title:
- No information
- Author:
- Urban, G. et al.
- Year:
- 1 994
- Bibliographic source:
- Chem. Res. Toxicol., 7(2):170-176 (BIOSIS/94/16152)
- Reference Type:
- publication
- Title:
- No information
- Author:
- Godin, C. S. et al.
- Year:
- 1 993
- Bibliographic source:
- Drug Metab. Dispos., 21(3):551-553
- Reference Type:
- publication
- Title:
- Gas uptake pharmacokinetics of 2,2- dichloro-1,1,1-trifluoroethane (HCFC-123)
- Author:
- Loizou GD, Urban G, Dekant W, Anders MW.
- Year:
- 1 994
- Bibliographic source:
- Drug Metab. Dispos., 22(4):511-517 (NIOSH/00222612)
Materials and methods
- Objective of study:
- metabolism
Test guideline
- Qualifier:
- no guideline available
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2,2-dichloro-1,1,1-trifluoroethane
- EC Number:
- 206-190-3
- EC Name:
- 2,2-dichloro-1,1,1-trifluoroethane
- Cas Number:
- 306-83-2
- Molecular formula:
- C2HCl2F3
- IUPAC Name:
- 2,2-dichloro-1,1,1-trifluoroethane
- Reference substance name:
- Ethane,2,2-dichloro-1,1,1-trifluoro-
- IUPAC Name:
- Ethane,2,2-dichloro-1,1,1-trifluoro-
- Details on test material:
- - Name of test material (as cited in study report): HCFC-123
Constituent 1
Constituent 2
- Radiolabelling:
- yes
- Remarks:
- 14-C-HCFC 123
Test animals
- Species:
- other: Rat and guinea pig
- Strain:
- other: Sprague Dawley rats and Hartley guinea pigs
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: gas
- Vehicle:
- unchanged (no vehicle)
- Duration and frequency of treatment / exposure:
- 6 hours
Doses / concentrations
- Remarks:
- Doses / Concentrations:
2000 ppm (metabolic study); 500 and 5000 ppm in toxicokinetic study
- Control animals:
- not specified
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Uptake studies carried out with 14C-HCFC 123 in rats indicated that a single saturable component was involved in both sexes without significant differences between males and females in in vivo metabolic constants. An uptake of about 56-60% of the applied radioactivity was observed in rats, whereas about 95% uptake was recorded in guinea pigs.
- Details on distribution in tissues:
- Low radioactivity % were recorded in the analysed organs (liver, kidney, lung, brain, pancreas, testes and spleen). A low but measurable covalent binding to proteins was observed in liver, followed by the lung and the kidney.
- Details on excretion:
- The excretion of the major metabolite trifluoroacetic acid appeared to be suject to a saturable mechanism. After 48 hours, excretion accounted for about 20-30% of the applied radioactivity in rats and guinea pigs. As no complete mass balance was undertaken, the loss of the remaining radiolabelled substance was unknown, but presumably absorbed.
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- The in vitro metabolism of HCFC-123 was examined in rat and human liver microsomes. The major metabolite in both species was trifluoroacetic acid. Chlorodifluoroacetic acid and inorganic fluoride were also identified as products of the enzymatic oxidation of HCFC-123. Microsomes from rats treated with ethanol and pyridine, inducers of P450 2E1, metabolized HFC-123 at higher rates. The microsomes also exhibit high rates of p-nitrophenol oxidation, a substrate mainly metabolized by P450 2E1. Trifluoroacetic acid formation was significantly reduced by the P450 2E1 inhibitor diethylthiocarbamate; p-nitrophenol also inhibited HCFC-123 oxidation in rat and human microsomes.
In vivo: trifluoroacetic acid was identified as the major metabolites excreted in urine by rats and guinea pigs. Minor metabolites were N-trifluoroacetyl-2- aminoethanol and N-acetyl-S-(2,2-dichloro-1,1-difluoroethyl)-L-cysteine.
The metabolic pathway of HCFC 123 was proposed (see figure 1)
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
