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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Additional information

HCFC 123 has a low acute toxicity following oral, dermal and inhalatory exposure. However, signs of CNS depression and sublethal toxic changes in the liver were observed in acute toxicity experiments.

Oral exposure

An approximate lethal concentration of 9000 mg/kg in male rats administered via gavage was reported by Haskell (1975).


Studies in rats, hamsters and guinea pigs are available. 4 -h exposure in rats (ECETOC, 2005) and hamsters (Allied Signal, 1981) gave consistent results with LC50 of 32000 and 28400 ppm, respectively. CNS depression was observed to occur during the exposure period in those studies, with full recovery of the surviving animals shortly after the cessation of the exposure.

No lethality was observed in guinea pigs exposed up to 30000 ppm for 4 hours, but hepatoxicity was observed at 1000 ppm and above (Marit et al., 1994).

Dermal exposure

Acute dermal toxicity was studied in rats (Haskell, 1988a) and rabbits (Haskell, 1988b). In both studies, no lethality was observed up to the highest tested dose of 2000 mg/kg. No clinical signs were noted in the rabbit study, whereas red nasal and ocular discharges were noted in 2 rats exposed to 2000 mg/kg. No signs of skin irritation were recorded. A slight bodyweight loss was also observed at the end of the 14 -day recovery period.

Justification for classification or non-classification

HCFC 123 does not meet the criteria for acute toxicity classification in accordance with EU Directive 67/548/EEC and EU Classification, Labeling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.

In accordance with Directive 67/548/EEC, HCFC 123 is classified as Harmful - possible risk of irreversible effects (Xn R68/20) in view of the significant hepatotoxicity observed in guinea pigs and to the reported data in humans (see Section 7.10.5)

In accordance with Regulation EC 1272/2008 HCFC 123 is classifiable as STOT-SE Category 2 (H371) in view of the weight of evidence (significant hepatotoxicity observed in guinea pigs and reported human data).