Registration Dossier
Registration Dossier
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EC number: 206-190-3 | CAS number: 306-83-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable study. No GLP followed, not in line with OECD TG
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2,2-dichloro-1,1,1-trifluoroethane
- EC Number:
- 206-190-3
- EC Name:
- 2,2-dichloro-1,1,1-trifluoroethane
- Cas Number:
- 306-83-2
- Molecular formula:
- C2HCl2F3
- IUPAC Name:
- 2,2-dichloro-1,1,1-trifluoroethane
- Reference substance name:
- Ethane,2,2-dichloro-1,1,1-trifluoro-
- IUPAC Name:
- Ethane,2,2-dichloro-1,1,1-trifluoro-
- Details on test material:
- - Name of test material (as cited in study report): Ethane, 1,1-dichloro-2,2,2-trifluoro, FC-123
- Structural Formula: CHCl3CF3
- Analytical purity: 99.9405%
-Lot No.: Cylinder #'s: 454842 and 485867
- Physical state: liquid
- Source: Howard E. Phillips, Organic Chemicals Department, Chestnut Run
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- other: ChR-CD
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- no data
- Doses:
- 15,024 mg/kg, 13,934 mg/kg, 11,000 mg/kg, 9,000 mg/kg, 7,500 mg/kg, 5,000 mg/kg, 3,400 mg/kg, 2,250 mg/kg
- No. of animals per sex per dose:
- One male per dose level
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- other: Approximately Lethal Dose (ALD)
- Effect level:
- 9 000 mg/kg bw
- Mortality:
- Mortality occurred within 3 minutes at dose levels of 11,000, 13,934, and 15,024 mg/kg. Death occurred within 1 hour at 9000 mg/kg.
- Clinical signs:
- other: Lethal dose: rapid respiration; Sub-lethal dose: rapid shallow respiration and belly to cage posture on day dosing at 3400 mg/kg and above; wet perineal area on day after dosing at 5000 mg/kg and 7500 mg/kg
- Gross pathology:
- no data
- Other findings:
- no data
Applicant's summary and conclusion
- Conclusions:
- Ethane, 1,1-dichloro-2,2,2-trifluoro has a low toxicity when administered orally in single doses to young adult male ChR-CD rats; its Approximate Lethal Dose (ALD) is 9,000 mg/kg of body weight.
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