Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable study. No GLP followed, not in line with OECD TG

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975
Report date:
1975

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2,2-dichloro-1,1,1-trifluoroethane
EC Number:
206-190-3
EC Name:
2,2-dichloro-1,1,1-trifluoroethane
Cas Number:
306-83-2
Molecular formula:
C2HCl2F3
IUPAC Name:
2,2-dichloro-1,1,1-trifluoroethane
Constituent 2
Reference substance name:
Ethane,2,2-dichloro-1,1,1-trifluoro-
IUPAC Name:
Ethane,2,2-dichloro-1,1,1-trifluoro-
Details on test material:
- Name of test material (as cited in study report): Ethane, 1,1-dichloro-2,2,2-trifluoro, FC-123
- Structural Formula: CHCl3CF3
- Analytical purity: 99.9405%
-Lot No.: Cylinder #'s: 454842 and 485867
- Physical state: liquid
- Source: Howard E. Phillips, Organic Chemicals Department, Chestnut Run

Test animals

Species:
rat
Strain:
other: ChR-CD
Sex:
male
Details on test animals or test system and environmental conditions:
no data

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
corn oil
Details on oral exposure:
no data
Doses:
15,024 mg/kg, 13,934 mg/kg, 11,000 mg/kg, 9,000 mg/kg, 7,500 mg/kg, 5,000 mg/kg, 3,400 mg/kg, 2,250 mg/kg
No. of animals per sex per dose:
One male per dose level
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
Statistics:
no data

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
other: Approximately Lethal Dose (ALD)
Effect level:
9 000 mg/kg bw
Mortality:
Mortality occurred within 3 minutes at dose levels of 11,000, 13,934, and 15,024 mg/kg. Death occurred within 1 hour at 9000 mg/kg.
Clinical signs:
Lethal dose: rapid respiration; Sub-lethal dose: rapid shallow respiration and belly to cage posture on day dosing at 3400 mg/kg and above; wet perineal area on day after dosing at 5000 mg/kg and 7500 mg/kg
Body weight:
no data
Gross pathology:
no data
Other findings:
no data

Applicant's summary and conclusion

Conclusions:
Ethane, 1,1-dichloro-2,2,2-trifluoro has a low toxicity when administered orally in single doses to young adult male ChR-CD rats; its Approximate Lethal Dose (ALD) is 9,000 mg/kg of body weight.