1-(dimethylamino)propan-2-ol

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Meets generally accepted scientific standards, well documented and acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1964

Report date:

1964

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Principles of method if other than guideline:

BASF-Test: The study was conducted according to an internal BASF method which in principle is comparable to the OECD Guideline 401.
A test group consisting of 5 animals/sex was treated by single gavage application with an aqueous solution of the test substance. The animals were observed for mortality and for clinical symptoms of toxicity. At the end of the observation period of 14 days, the surviving animals were sacrificed for the purpose of necropsy; animals that died during the observations period also were subjected to necropsy.

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

1-(dimethylamino)propan-2-ol

EC Number:

203-556-4

EC Name:

1-(dimethylamino)propan-2-ol

Cas Number:

108-16-7

Molecular formula:

C5H13NO

IUPAC Name:

1-(dimethylamino)propan-2-ol

Test material form:

liquid

Specific details on test material used for the study:

- Name of test material (as cited in study report): Dimethyl-isopropanolamin
- Physical state: liquid
no further data

Test animals

Species:

rat

Strain:

other: US-rats

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: males: 148-314 g, females: 110-170 g

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

water

Details on oral exposure:

VEHICLE
- Concentration in vehicle: 2% or 20 % v/v

MAXIMUM DOSE VOLUME APPLIED:
16 ml/kg bw

Doses:

170, 680, 1360, 1700, 2125, 2720 mg/kg bw

No. of animals per sex per dose:

5-10

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 7 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Statistics:

no data

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

ca. 1 360 mg/kg bw

Based on:

test mat.

Remarks on result:

other: ca. 1.6 ml/kg 20% (v/v)

Mortality:

0/10 animals died at 170 mg/kg bw
0/10 animals died at 680 mg/kg bw
10/20 animals died at 1360 mg/kg bw
10/20 animals died at 1700 mg/kg bw
6/10 animals died at 2125 mg/kg bw
9/10 animals died at 2720 mg/kg bw
deaths occured within day 1-3

Clinical signs:

other: On the day of administration: apathy, staggering, dyspnoea. On the following days: calm behaviour, fluffy fur, crusted eyes. The surviving aninmals were without findings within 4-6 days.

Gross pathology:

haemorrhagic gastroenteritis in the dead animals, organs of the surviving animals without findings

Applicant's summary and conclusion

Interpretation of results:

Category 4 based on GHS criteria

Conclusions:

oral LD50(rat) = ca. 1360 mg/kg bw