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Physical & Chemical properties

Stability in organic solvents and identity of relevant degradation products

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Reference
Endpoint:
stability in organic solvents and identity of relevant degradation products
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
comparable to guideline study
Justification for type of information:
Experimental test result performed using standard test guidelines
Qualifier:
according to guideline
Guideline:
other: GC-MS
Principles of method if other than guideline:
Changes in Mass Spectra after dissolving in solvents
GLP compliance:
no
Other quality assurance:
ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)
Test substance stable:
yes
Transformation products:
no

No degradation was observed in organic solvents - methanol, hexane and acetone. The degradation products in dichloromethane were analysed using GC-MS spectroscopic technique.

Conclusions:
The test substance is more or less stable in organics solvents because no degradation was observed in hexane, methanol and acetone. Minor degradation was observed in dichloromethane but no major peaks in GC-MS spectra were seen. On the basis of the spectra, the substance test chemical is concluded to be stable in organic solvents.
Executive summary:

The test substance is more or less stable in organics solvents because no degradation was observed in hexane, methanol and acetone. Minor degradation was observed in dichloromethane but no major peaks in GC-MS spectra were seen. On the basis of the spectra, the substance test chemical is concluded to be stable in organic solvents.

Description of key information

The test substance is more or less stable in organics solvents because no degradation was observed in hexane, methanol and acetone. Minor degradation was observed in dichloromethane but no major peaks in GC-MS spectra were seen. On the basis of the spectra, the substance test chemical is concluded to be stable in organic solvents

Additional information

The test substance is more or less stable in organics solvents because no degradation was observed in hexane, methanol and acetone. Minor degradation was observed in dichloromethane but no major peaks in GC-MS spectra were seen. On the basis of the spectra, the substance test chemical is concluded to be stable in organic solvents