Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 942-322-2 | CAS number: -
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- GLP guideline study According to the ECHA guidance document “Practical guide 6: How to report read-across and categories (March 2010)”, the reliability was changed from RL1 to RL2 to reflect the fact that this study was conducted on a read-across substance.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
- Reference Type:
- secondary source
- Title:
- SIDS Category of Alkyl sulfates, Alkane sulfonates and Alpha-olefin sulfonates
- Author:
- OECD
- Year:
- 2 007
- Bibliographic source:
- UNEP Publications
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
- Deviations:
- yes
- Remarks:
- lack of details on test substance
- GLP compliance:
- yes
- Type of assay:
- micronucleus assay
Test material
- Reference substance name:
- Sulfuric acid, mono-C12-14-alkyl esters, compds. with triethanolamine
- EC Number:
- 292-216-9
- EC Name:
- Sulfuric acid, mono-C12-14-alkyl esters, compds. with triethanolamine
- Cas Number:
- 90583-18-9
- IUPAC Name:
- Sulfuric acid, mono-C12-14-alkyl esters, compds. with triethanolamine
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: CFW 1
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- According to guideline.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- Aqua bidest.
- Duration of treatment / exposure:
- 24 h (all doses)
48, 72 h (4000 mg/kg bw) - Frequency of treatment:
- single
- Post exposure period:
- n.a.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
400, 2000, 4000 mg/kg bw
Basis:
nominal conc.
- No. of animals per sex per dose:
- 7
- Control animals:
- yes, concurrent vehicle
- Positive control(s):
- Yes
Examinations
- Details of tissue and slide preparation:
- TREATMENT AND SAMPLING TIMES:
400 and 2000 mg/kg bw: after 24 hours
4000 mg/kg bw group: after 24, 48 and 72 hours
control groups: after 24 hours - Evaluation criteria:
- According to guideline.
- Statistics:
- Yes.
Results and discussion
Test results
- Sex:
- male/female
- Genotoxicity:
- negative
- Toxicity:
- no effects
- Vehicle controls validity:
- valid
- Negative controls validity:
- not applicable
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
The test item was not considered to be clastogenic. - Executive summary:
No increase in micronucleated polychromatic erythrocytes was observed in this micronucleus test. Therefore, the test substance was not considered to be clastogenic.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
