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EC number: 605-315-2 | CAS number: 163149-28-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: This study is classified as reliable without restriction because it closely followed OECD Guideline 405 and was GLP compliant.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 68649-12-7
- EC Number:
- 614-695-9
- Cas Number:
- 68649-12-7
- IUPAC Name:
- 68649-12-7
- Details on test material:
- - Name of test material (as cited in study report): Emery 3004
- Substance type: Poly Alpha Olefin (1-decene trimer and tetramer, hydrogenated)
- Physical state: Liquid
- Analytical purity: Not reported
- Lot/batch No.: #8BU28
- Stability under test conditions: Not reported
- Storage condition of test material: Room temperature
- Other: Clear liquid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Clerco Research Farm
- Age at study initiation: Not reported
- Weight at study initiation: Not reported
- Housing: Individual in wire mesh cages
- Diet (e.g. ad libitum): Purina Laboratory Rabbit Chow ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 1 day
ENVIRONMENTAL CONDITIONS
- Temperature (°C): Not reported
- Humidity (%): Not reported
- Air changes (per hr): Not reported
- Photoperiod (hrs dark / hrs light): 12 hrs dark/12 hrs light
IN-LIFE DATES: From: 1988-03-23 To: 1988-03-31
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 millilitres
- Concentration (if solution): Not reported - Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- 72 hours
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): No washing
SCORING SYSTEM: Method of Draize (1959)
TOOL USED TO ASSESS SCORE: Gross ocular examinations only
Results and discussion
In vivo
Results
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: 1 and 6
- Time point:
- other: 72 hours
- Score:
- > 0 - < 2
- Max. score:
- 2
- Reversibility:
- not specified
- Irritant / corrosive response data:
- Two animals showed signs of conjunctival erythema; for one, signs cleared up by 72 hours, while for the other, signs appeared at 72 hours.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on the reported results, Emery 3004 was not classified as an irritant to rabbit eyes.
- Executive summary:
In a primary eye irritation study, 0.5 mL of Emery 3004 (Undiluted) was instilled into the right eye of 6 naïve female New Zealand White rabbits for 24 hours. Eyes of the test animals were not rinsed post exposure. Animals then were observed for 72 hours and irritation was scored by the method of Draize (1959).
Two animals showed signs of conjunctival erythema; for one, signs cleared up by 72 hours, while for the other, signs appeared at 72 hours. Based on the reported results, Emery 3004 is not an eye irritant.
This study received a Klimisch score of 1 and is classified as reliable without restriction because it closely followed OECD Guideline 405 and was GLP compliant.
This study will influence the DNEL.
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