Naphthalenesulfonic acids, branched and linear Bu derivs., sodium salts

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1971

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1971

Report date:

1971

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: USDA Regulation (Federal Register 34, No. 64, April 4, 1969)

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Naphthalenesulfonic acids, branched and linear Bu derivs., sodium salts

EC Number:

293-346-9

EC Name:

Naphthalenesulfonic acids, branched and linear Bu derivs., sodium salts

Cas Number:

91078-64-7

Molecular formula:

Not applicable (UVCB substance)

IUPAC Name:

Reaction products of naphtalene, butanol, sulfonated and neautralized by caustic soda

Test material form:

solid: particulate/powder

Test animals / tissue source

Species:

rabbit

Strain:

other: Albino rabbits

Test system

Controls:

other: untreated eye

Duration of treatment / exposure:

72 hours

Observation period (in vivo):

24, 48 and 72 hours

Number of animals or in vitro replicates:

6 albino rabbit

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

other: irritation

Basis:

animal: 21 and 27

Time point:

24/48/72 h

Score:

0

Remarks on result:

other:

Remarks:

Irritation effects: positive after 24 h; negative after 48 h and 72 h.

Results 2

Irritation parameter:

other: irritation

Basis:

animal: 22, 23, 24 and 26

Time point:

24/48/72 h

Score:

0

Remarks on result:

other:

Remarks:

Irritation effects: positive after 24, 48 and 72 h.

Any other information on results incl. tables

The results are shown in the following table.

Animal number	Irritant effect on the eye
	after 24 hours	after 48 hours	after 72 hours
21	pos.	neg.	neg.
22	pos.	pos.	pos.
23	pos.	pos.	pos.
24	pos.	pos.	pos.
26	pos.	pos.	pos.
27	pos.	neg.	neg.

Result: distinct irritant effect on the mucosa

Applicant's summary and conclusion

Interpretation of results:

other: classified as an eye irritant according to the CLP Regulation (EC) No.1272/2008

Conclusions:

The test item caused distinct irritation of the mucosa of the eye in the rabbit.

Executive summary:

The eye irritation potential of the substance was evaluated following the USDA Regulation (Federal Register 34, No. 64, April 4, 1969). Six albino rabbits were exposed to the substance for 72 hours; the untreated eye was used as a control. The eyes of the rabbits were evaluated at 24 -48 -72 hours.

The test item caused distinct irritation of the mucosa of the eye in the rabbit.