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Registration Dossier
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EC number: 203-960-0 | CAS number: 112-33-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable publication but only limited data is given. (number of animals that died not given, symptoms not described; no necropsy; purity of test substance not given).
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 969
Materials and methods
- Principles of method if other than guideline:
- Method: according to Smyth, Carpenter, Weil, Pozzani and Striegel: Range-Finding Toxicity Data: List VI, Amer. Ind. Hyg. Assoc. J. 23: 95 (1962), for details see any other information on materials ans methods
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- 2-[2-(3-aminopropoxy)ethoxy]ethanol
- EC Number:
- 203-960-0
- EC Name:
- 2-[2-(3-aminopropoxy)ethoxy]ethanol
- Cas Number:
- 112-33-4
- Molecular formula:
- C7H17NO3
- IUPAC Name:
- 2-[2-(3-aminopropoxy)ethoxy]ethan-1-ol
- Details on test material:
- - Name of test material (as cited in study report): 3-Aminopropoxy-2-ethoxy ethanol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Carworth-Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: from own colony at testing lab
- Age at study initiation: 4 to 5 weeks
- Weight at study initiation: 90 to 120 g
- Fasting period before study: not fasted
- Diet: Rockland rat diet, complete; ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: solution as needed: in water, corn oil or suspension in semi-solid agar (not specified)
- Doses:
- The dosages are arranged in a logarithmic series differing by a factor of 2. Whenever possible, the chemical is administered undiluted. When a lesser concentration is necessary a suitable vehicle is used.
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: not specified
- Necropsy of survivors performed: no - Statistics:
- Based upon mortalities during a 14 day observation period, the most probable LD50 value and its fiducial range are estimated by the method of Thompson (Thompson W.R.: Use of Moving Averages and Interpolation to estimate Median Effective Dose, Bacteriol. Rev. 11: 115, June 1947) using Tables of Weil (Weil C. S.: Tables for convenient calculation of Median-Effective Dose (LD50 or ED50) and Instructions in their Use, Biometrics 8: 249, Sept. 1952).
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 6 500 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 4 950 - 8 530
- Mortality:
- no details given
- Clinical signs:
- other: no details given
- Gross pathology:
- no necropsy performed
Applicant's summary and conclusion
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