2-[2-(3-aminopropoxy)ethoxy]ethanol

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Acceptable publication but only limited data is given. (Concentration of vapour in saturated atmosphere is not given, no data on clinical signs and observations, no necropsy performed, no details on test material given.)

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

1969

Materials and methods

Principles of method if other than guideline:

Method: according to Smyth, Carpenter, Weil, Pozzani and Striegel: Range-Finding Toxicity Data: List VI, Amer. Ind. Hyg. Assoc. J. 23: 95 (1962) for details see any other information on materials and methods

GLP compliance:

no

Test type:

standard acute method

Test material

Test material information

Constituent 1

Reference substance name:

2-[2-(3-aminopropoxy)ethoxy]ethanol

EC Number:

203-960-0

EC Name:

2-[2-(3-aminopropoxy)ethoxy]ethanol

Cas Number:

112-33-4

Molecular formula:

C7H17NO3

IUPAC Name:

2-[2-(3-aminopropoxy)ethoxy]ethan-1-ol

Details on test material:

- Name of test material (as cited in study report): 3-Aminopropoxy-2-ethoxy ethanol

Test animals

Species:

rat

Strain:

other: albino

Sex:

male/female

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

air

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: rats are exposed to a flowing stream of vapour-ladened air
- Method of conditioning air: The vapour-air mixture is generated by passing 2.5 L/min of dried air at room temperature through a fritted glass disc immersed to a depth of at least one inch in approximately 50 mL of the test chemical contained in a gas-washing bottle.

TEST ATMOSPHERE
- Samples taken from breathing zone: no data

Analytical verification of test atmosphere concentrations:

not specified

Duration of exposure:

8 h

Concentrations:

no data

No. of animals per sex per dose:

6 males or females

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: not given
- Necropsy of survivors performed: no

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC0

Effect level:

other: concentration not given

Based on:

test mat.

Exp. duration:

8 h

Remarks on result:

other: no mortality observed

Mortality:

none

Clinical signs:

other: no data

Body weight:

no data

Gross pathology:

not performed

Any other information on results incl. tables

No mortality was observed when rats were exposed for up to 8 hours to an atmosphere that had been saturated at room temperature with the volatile part of the compound.