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Toxicological information

Dermal absorption

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Administrative data

Endpoint:
dermal absorption in vitro / ex vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: non-GLP and not OECD compliant study

Data source

Reference
Reference Type:
publication
Title:
Enhancement in skin permeation of 5-aminolevulinic acid using l-menthol and its derivatives
Author:
Tokuoka Y, Suzuki M, Ohsawa Y, Ochiai A, Ishizuka M, Kawashima N
Year:
2008
Bibliographic source:
PMID:18568909 Drug Dev Ind Pharm 34(6):595-601

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Enhancing effect of l-menthyl acetate on skin permeation of 5-aminolevulinic acid (ALA) through Yucatan micropig full-thickness skin using a Franz-type diffusion cell
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Menthyl acetate
EC Number:
201-911-8
EC Name:
Menthyl acetate
Cas Number:
89-48-5
Molecular formula:
C12H22O2
IUPAC Name:
5-methyl-2-(propan-2-yl)cyclohexyl acetate
Radiolabelling:
no

Results and discussion

Any other information on results incl. tables

Over 16 h the cumulative amount of 5-aminolevulinic acid (ALA) is obviously the largest in the case of l-methyl acetate.

This would be caused by the small difference in inorganic/organic value ratio (0.33), or hydrophobicity of terpene. Permeability coefficient increased with decreasing inorganic/organic value ratio, or with increasing hydrophobicity of l-menthol and his derivative, reaching the maximum in the system with l-menthyl acetate. This finding suggests that l-menthyl acetate has the optimal hydrophobicity of l-menthol derivative for enhancing ALA skin permeation.

Applicant's summary and conclusion

Conclusions:
l-menthyl acetate is effective to enhance 5-aminolevulinic acid (ALA) skin permeation.