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EC number: 429-530-4 | CAS number: 96662-24-7
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30 September 1998
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- 4.3
- Remarks on result:
- other: pH and temp. not detailed in the study report
- Type:
- Pow
- Partition coefficient:
- 19 953
- Remarks on result:
- other: pH and temp. not detailed in the study report
- Details on results:
- For calibration the retention times of a series of "neutral" substances with known n-octanol/water partition coefficients were measured and a calibration graph according to equation was established.
The n-octanol/water partition coefficient of the test substance T-9601 was derived from its retention time and the calibration graph. - Conclusions:
- The objective of this study was the determination of the partition coefficient n-octanol/water of the test substance T-9601 according to guideline 92/69/EEC, appendix, A.8. The study was conducted in compliance with the Principles of Good Laboratory Practice(GLP).
The partition coefficient n-octanol/water of the test substance T-9601 has been determined according to the "HPLC method" as:
log Pow = 4.3
Pow = 19953
Reference
Description of key information
The log Pow of the Substance was determined to be 4.3.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 4.3
Additional information
The partition coefficient of the test item was determined by the HPLC method according to the European Commission Regulations (EC) No. 440/2008, A.8. partition coefficient n-octanol/water.
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