Registration Dossier
Registration Dossier
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EC number: 429-530-4 | CAS number: 96662-24-7
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26 July 2001
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted to OECD test guidance in compliance with GLP.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Version / remarks:
- Draft method utilised at the time of study.
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- HPLC estimation method
- Media:
- other: Soil and Sewage Sludge using High Performance Liquid Chromatography (HPLC)
- Radiolabelling:
- no
- Test temperature:
- 23.5 to 24.0 °C
- Details on study design: HPLC method:
- HPLC is performed on an analytical column packed with a commercially available cyanopropyl solid phase chemically bonded on silica. Chemicals injected on such a column move along it by partitioning between the mobile solvent phase and the cyanopropyl stationary phase. As a result of partitioning between mobile and stationary phase the test substances are retarded. The dual composition of the stationary phase having polar and non-polar sites allows for interaction of polar and non-polar groups of a molecule in a similar way as is the case for organic matter in soil matrices. This enables the relationship between the retention time on the column and the adsorption coefficient on organic matter to be established.
The adsorption coefficient (Koc) of the test substance is given as its log Koc value.
Analytical Parameters
The measurements were performed with the following HPLC conditions:
Equipment;HPLC Pump SP 8810, Spectra-Physics Inc. Differential Refractometer, Knauer Inc.
Conditions:
Stationary phase Zorbax CN, 250 x 4.6 mm, 5 urn
Mobile phase methanol / water (purified) 60/40 (v/v)
Flow velocity: 1.5 ml/min
Injection volume: 20 ul
Temperature: 23.5 to 24.0 °C
Detection: Refractive index
Calibration substances
(0) Urea (inert marker): 21.9 mg/25 ml eluent
(1) Monuron 13.5 mg/25 ml solvent
(2) Triapenthenol 17.2 mg/25 ml solvent
(3) Linuron 16.0 mg/25 ml solvent
(4) Fenthion 16.8 mg/25 ml solvent
(5) Trifluralin 14.7 mg/25 ml solvent
(6) 3,5-Dinitrobenzamide 14.2 mg/25 ml solvent
The solvent was methanol / water (purified) 70/30 (v/v). - Analytical monitoring:
- no
- Details on sampling:
- Not applicable.
- Details on matrix:
- Not applicable.
- Details on test conditions:
- Not applicable.
- Computational methods:
- Not applicable.
- Type:
- log Koc
- Value:
- 4.2
- Temp.:
- 23.5 °C
- Details on results (HPLC method):
- The adsorption coefficient on soil (Koc) of T-9601 was found to be 1.58x 10E+04 (log Koc = 4.2).
- Adsorption and desorption constants:
- Not measured
- Recovery of test material:
- Not measured
- Concentration of test substance at end of adsorption equilibration period:
- Not measured
- Concentration of test substance at end of desorption equilibration period:
- Not measured
- Validity criteria fulfilled:
- yes
- Conclusions:
- The adsorption coefficient on soil (Koc) of T-9601 was found to be 1.58x 10 E04 (log Koc=4.2).
- Executive summary:
The adsorption coefficient on soil of T-9601 was determined according OECD guidelines for the testing of chemicals, Draft Guideline No. 121: Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC)", August 1999.
The adsorption coefficient on soil (Koc) of T-9601 was found to be 1.58x 10E04 (log Koc = 4.2).
Reference
From the retention times of the test item T-9601 the corresponding k'-values were calculated and with the function above the log Koc of T-9601 was determined by extrapolation to:
t (minutes) |
k' |
logk' |
log Koc |
logKoc(mean value) |
15.42 |
5.734 |
0.758 |
4.22 |
|
|
|
|
|
4.2 |
14.97 |
5.537 |
0.743 |
4.19 |
|
There is no greater difference than 0.1 between the two values and the corresponding mean value
Description of key information
The adsorption coefficient on soil (Koc) of T-9601 at 23.5°C was found to be 1.58x 10 E04 (log Koc=4.2).
Key value for chemical safety assessment
Additional information
The adsorption coefficient on soil of T-9601 was determined according OECD guidelines for the testing of chemicals, Draft Guideline No. 121: Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC)", August 1999.
The adsorption coefficient on soil (Koc) of T-9601 at 23.5°C was found to be 1.58x 10E04 (log Koc = 4.2).
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