Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

Additional information

No experimental studies investigating the bioaccumulation potential ofBis(2-(2-butoxyethoxy)ethyl) adipate (CAS 141-17-3) are available. Therefore, the bioaccumulation factor (BCF) of the substance was estimated using a reliable QSAR model (BCFBAF v3.01). The substance is in the applicability domain of the model indicating that the results are reliable and can be used to assess the bioaccumulation potential of Bis(2-(2-butoxyethoxy)ethyl) adipate. Using the Arnot-Gobas method, including biotransformation (BCFBAF v3.01, Arnot Gobas, upper trophic), a BCF value of 6.33 L/kg was calculated. An exclusion of biotransformation resulted in a higher BCF of 184 L/kg, indicating that extensive metabolism occurs and significantly reduces the bioaccumulation potential in a short period of time. The QSAR estimated biological half-life is 0.00588 days (corresponding to approx. 8 min). For a detailed review on metabolism of the substance, please refer to the toxicokinetics statement in Chapter 7.1 of the technical dossier. Based on the valid QSAR calculation, it can be concluded that Bis(2-(2-butoxyethoxy)ethyl) adipate has a low potential for bioaccumulation. The calculated BCF values, with and without metabolism, are clearly below the trigger value of 2000 L/kg to be classified as bioaccumulative (B-criterion) in the PBT assessment.