Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 206-735-5 | CAS number: 371-40-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicity to terrestrial plants
Administrative data
- Endpoint:
- toxicity to terrestrial plants: short-term
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Reaxys ID : 742030
- Year:
- 2 011
- Bibliographic source:
- Reaxys by Elsevier Properties SA; Wang, Xiaodong; Sun, Cheng; Wang, Liansheng; Han, Shuokui; Environmental Toxicology and Chemistry; vol. 20; nb. 4; (2001); p. 913 - 916
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Germination test:- Semistatic exposure of 15 seeds germinated in solution of test compounf for 48 h in dark at 25 deg C and pH 6.75; The germination rate was calculated.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-fluoroaniline
- EC Number:
- 206-735-5
- EC Name:
- 4-fluoroaniline
- Cas Number:
- 371-40-4
- Molecular formula:
- C6H6FN
- IUPAC Name:
- 4-fluoroaniline
- Details on test material:
- - Name of test material: 4-fluoroaniline
- Molecular formula: C6H6FN
- Molecular weight: 111.12
- Substance type: Organic
- Physical state: Liquid
Constituent 1
Sampling and analysis
- Analytical monitoring:
- not specified
Test substrate
- Vehicle:
- yes
- Details on preparation and application of test substrate:
- Kind of Dosing : solution of title compound in water was applied
Test organisms
- Species:
- Cucumis sativus
- Plant group:
- Dicotyledonae (dicots)
Study design
- Test type:
- seed germination/root elongation toxicity test
- Study type:
- laboratory study
- Substrate type:
- other: solution of title compound
- Total exposure duration:
- 48 h
Test conditions
- Test temperature:
- 25 deg C;
- pH:
- 6.75
- Details on test conditions:
- 15 seeds were germinated in solution of title compound for 48 h by semistatic exposure in dark at 25 deg C and pH 6.75
Control used: without test compound - Nominal and measured concentrations:
- 6 concentrations from no effect to 100 percent inhibition concentrations were used
Results and discussion
Effect concentrations
- Species:
- Cucumis sativus
- Duration:
- 48 h
- Dose descriptor:
- other: GC50
- Effect conc.:
- 519 other: mg/l
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- dissolved
- Basis for effect:
- germination
- Remarks on result:
- other: log 1/GC50 = 2.33
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The GC50 (inhibited germination rate by 50 percent) value of 4-fluoroaniline to Cucumis sativus during a 48 hr exposure is 519 mg/L.
- Executive summary:
The GC50 (inhibited germination rate by 50 percent) value of 4-fluoroaniline to Cucumis sativus during a 48 hr exposure is 519 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
