Registration Dossier
Registration Dossier
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EC number: 206-735-5 | CAS number: 371-40-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- RTECS Number: BY1575000
- Year:
- 2 012
- Bibliographic source:
- RTECS (Registry of Toxic Effects of Chemical Substances):- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,611,1986
- Reference Type:
- review article or handbook
- Title:
- DPIM: FFY000
- Author:
- Richard J. Lewis, Sr.
- Year:
- 2 007
- Bibliographic source:
- SAX (Sax's Handbook of Dangerous Industrial Materials):85JCAE ;Prehled Prumyslove Toxikologie; Organicke Latky Marhold, J., Prague, Czechoslovakia.: , Avicenum 1986, 611.
- Reference Type:
- review article or handbook
- Title:
- Dose doc.no. : F60
- Author:
- RSC Publishing
- Year:
- 2 011
- Bibliographic source:
- Dictionary of Substances and their effects (DOSE);Marhold, J. V. Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku 1972, 95, Prague, Czechoslovakia
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Standard Draize test
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-fluoroaniline
- EC Number:
- 206-735-5
- EC Name:
- 4-fluoroaniline
- Cas Number:
- 371-40-4
- Molecular formula:
- C6H6FN
- IUPAC Name:
- 4-fluoroaniline
- Details on test material:
- - Name of test material: 4-fluoroaniline
- Molecular formula: C6H6FN
- Molecular weight: 111.12
- Substance type: Organic
- Physical state: Liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- 2 mg
- Duration of treatment / exposure:
- 24hr
- Observation period:
- no data
- Number of animals:
- no data
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24 hr
- Reversibility:
- no data
- Remarks on result:
- other: Severe irritation
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- 2 mg of 4-fluoroaniline caused severe irritation to rabbit skin during a 24 hr exposure as evaluated by a Standard Draize test
- Executive summary:
2 mg of 4-fluoroaniline caused severe irritation to rabbit skin during a 24 hr exposure as evaluated by a Standard Draize test.
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