Registration Dossier
Registration Dossier
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EC number: 207-236-5 | CAS number: 455-14-1
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Only one study (Chrysalis, 1995) with reliability 1 was available and was selected as key study. The summary of this study is the following:
In a dermal sensitization study (Chrysalis, 1995) with p-trifluoromethylaniline in absolute ethanol, Hartley guinea pigs (10/sex in test groups and 5/sex in control group) were tested using the method of maximization.
2/20 animals presented positive reaction. It is not sufficient to consider p-TFMA for sensitization. 30% of positive reaction is necessary to classify a test item as skin sensitizer.
Burnt appearance of the skin on a surface less than one quarter of the application area was noted for 2 males. 1 male and 2 females presented scratches to the application area.
At dose of 1%, p-trifluoromethylaniline was not considered as dermal sensitizer, according to the EC classification criteria (67/548/EC directive) and CLP criteria.
Migrated from Short description of key information:
p-TFMA is not sensitizing at 1% concentration in a maximization test.
Justification for classification or non-classification
Based on results of the available study, p-TFMA could be considered as not sensitizing.
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