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Administrative data

Description of key information

No data are available for Glycerides, C16-18 mono-, di- and tri-, hydrogenated, citrates. Therefore, available data for the analogue substance CAS 91744-23-9 are used in a read-across approach. For details please refer to the read-across report.
The analogue substance CAS 91744-23-9 is practically non-irritating in primary skin and eye irritation tests according to OECD 404 and OECD 405, respectively, when applied at a concentration of 0.5 g to the shaved skin or 0.1g instilled into the eyes of albino rabbits.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

No data are available for Glycerides, C16 -18 mono-, di- and tri-, hydrogenated, citrates. Therefore, available data for the analogue substance CAS 91744-23-9 are used in a read-across approach. For details please refer to the read-across report.

Dermal irritation of the analogue substance CAS 91744-23-9 was investigated according to OECD 404 . 0.5 g of the test substance were applied to the skin of three New Zealand White rabbits (semi-occlusive coverage) for 4 h. Thereafter, the test substance was removed using warm water.

Observations were made after 30-60 minutes, 24, 48, and 72 h, as well as 6, 8, and 14 days after patch removal. An adjacent area of untreated skin served as control.

Mean erythema and edema scores after 24, 48, and 72 h were 1.67 and 1.11, respectively. Both were fully reversible within 14 days.

Based on the results of this test the substance is slightly irritating but does not warrant classification according to CLP. This conclusion is supported by the negative result from a patch test in human volunteers (section 7.10).

Eye irritation of the test substance was investigated in a study according to OECD 405 and GLP. 0.1 cm³ of the test substance were instilled in one eye each of the three New Zealand White rabbits. Total exposure was 24 h. Thereafter, the test substance was removed using warm physiological saline.

Observations were made after 1, 24, 48, and 72 h after administration. The untreated eye of each animal served as control.

Marked hyperaemias of some blood vessels could be observed in all animals 1 h after application, after 24 hours no effects was noticed. Mean scores for cornea, iris, conjunctivae redness and conjunctivae chemosis after 24, 48, and 72 h were 0 for each endpoint.

Based on the results of this test, the test substance is not irritating to the eye.


Justification for selection of skin irritation / corrosion endpoint:
No data are available for Glycerides, C16-18 mono-, di- and tri-, hydrogenated, citrates. Therefore, available data for the analogue substance CAS 91744-23-9 are used in a read-across approach. For details please refer to the read-across report.

Justification for selection of eye irritation endpoint:
No data are available for Glycerides, C16-18 mono-, di- and tri-, hydrogenated, citrates. Therefore, available data for the analogue substance CAS 91744-23-9 are used in a read-across approach. For details please refer to the read-across report.

Justification for classification or non-classification

The test substance is slightly irritating in skin but does not warrant classification according to CLP.

Based on the results of the OECD 405 test the test item is not irritating to the eye.