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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
Not specified
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment
Remarks:
Test result presented presented in an overview document for EPA reporting

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1978
Report date:
1978

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Not specified
Version / remarks:
Only the results are presented in a cover letter as reporting to EPA according to Section 8 (d) of the Toxic Substances Control Act (Fed. Vol. 54, No. 38, Tuesday, February 28, 1989)
Deviations:
not specified
Principles of method if other than guideline:
EPA reporting rule on certain pesticide inert ingredients. No specific methodology is reported.
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Dichlorodifluoromethane
EC Number:
200-893-9
EC Name:
Dichlorodifluoromethane
Cas Number:
75-71-8
Molecular formula:
CCl2F2
IUPAC Name:
dichlorodifluoromethane
Test material form:
aerosol dispenser: not specified
Remarks:
migrated information: aerosol
Details on test material:
Not specified

Test animals

Species:
other: species not specified.
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
Not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
not specified
Details on inhalation exposure:
Not specified
Analytical verification of test atmosphere concentrations:
not specified
Remarks on duration:
Not specified
Concentrations:
Not specified
No. of animals per sex per dose:
Not specified
Control animals:
not specified
Details on study design:
Not specified
Statistics:
Not specified

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
LC50
Effect level:
> 800 000 ppm
Based on:
not specified
Sex:
not specified
Dose descriptor:
LC50
Effect level:
3 956 155.419 mg/m³ air
Based on:
not specified
Remarks on result:
other: Conversion based on ACGIH ("2010 TLVs and BEIs, Based on the Documentation of the Threshold LImit Values for Chemical Substances and Physical Agents & Biological Exposure Indices")
Mortality:
No deaths
Clinical signs:
other: Not specified
Body weight:
Not specified
Gross pathology:
Not specified
Other findings:
No data

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
LC50 > 800,000 ppm. Although limited, the data set in the report indicates that the substance is not acutely harmful by inhalation exposure, and supports the weight of evidence approach for the substance. This matches the experience of handling and use of the substance. The substance is not deemed to be classified on the basis of inhalation toxicity.
Executive summary:

LC50 > 800,000 ppm (equates to 3956155.419 mg/m3). Although limited, the data set in the report indicates that the substance is not acutely harmful by inhalation exposure, and supports the weight of evidence approach for the substance. This matches the experience of handling and use of the substance. The substance is not deemed to be classified on the basis of inhalation toxicity.