Registration Dossier
Registration Dossier
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EC number: 202-764-2 | CAS number: 99-54-7
Health surveillance data
Administrative data
- Endpoint:
- health surveillance data
- Type of information:
- other: secondary literature
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary literature Documentation insufficient for assessment
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Hygienic characteristics of propanide manufacture.
- Author:
- Russkikh VA and Lubyanskii ML
- Year:
- 1 984
- Bibliographic source:
- Gig Tr Prof Zabol 3: 13-16 (Study in Russian; cited from: BUA Report 52 (1,2-Dichloronitrobenzenes), dated Juli 1990)
Materials and methods
- Study type:
- health record from industry
- Principles of method if other than guideline:
- migrated dataset
Test material
- Reference substance name:
- 1,2-dichloro-4-nitrobenzene
- EC Number:
- 202-764-2
- EC Name:
- 1,2-dichloro-4-nitrobenzene
- Cas Number:
- 99-54-7
- Molecular formula:
- C6H3Cl2NO2
- IUPAC Name:
- 1,2-dichloro-4-nitrobenzene
- Details on test material:
- migrated dataset
Constituent 1
Method
- Details on study design:
- migrated dataset
Results and discussion
- Results:
- migrated dataset
Any other information on results incl. tables
RS-Freetext:
The authors reported the results of a 2.5 year study on the
health of workers exposed at a 1,2-dichloro-4-nitrobenzene
processing plant in the former USSR. The workers were
exposed essentially to 1,2-dichloro-4-nitrobenzene,
3,4-dichloroaniline and 3,4-dichloropropionic acid anilide.
The skin was affected (chloracne) and also alterations of
peripheral blood including instable methaemoglobinaemia
appearance of Heinz bodies, a tendency towards
reticulolymphocytosis and thrombocytosis, bilirubinaemia and
dysproteinaemia. The exposure risk was suspected via dermal
absorption due to the low vapour pressure and the working
conditions. Measurements for uncovered skin gave exposures
to 0.002 - 0.2 mg/dm2 1,2-dichloro-4-nitrobenzene and
3,4-dichloroaniline and for covered skin (clothes) 0.0013 -
0.02 mg/dm2.
For 1,2-dichloro-4-nitrobenzene and 3,4-dichloroaniline the
mean individual dermal exposure per shift was given with
2.535 mg, while after cleaning of the skin the mean
individual burden was still 1.066 mg.
Due to the mixed exposure an association of the findings
with exposure to 1,2-dichloro-4-nitrobenzene is uncertain.
Applicant's summary and conclusion
- Executive summary:
migrated dataset
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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