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EC number: 244-005-8 | CAS number: 20748-72-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable non-GLP study, comparable to guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- not applicable
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- Before OECD Guideline 404 was first adopted in 1981, skin irritation was tested using a BASF test.
The methods were based on Draize (Federal Register 38, No. 187, § 1500.41, p. 27019 (1973-09-27)). - GLP compliance:
- no
Test material
- Reference substance name:
- 2-hydroxyethylammonium chloride
- EC Number:
- 217-900-6
- EC Name:
- 2-hydroxyethylammonium chloride
- Cas Number:
- 2002-24-6
- IUPAC Name:
- 2-hydroxyethanaminium chloride
- Details on test material:
- - Name of test material: Härter 421 flüssig; Äthanolaminhydrochlorid 45 % (German)
- Physical state: liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- No data
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: intact and abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- 5 minutes, 2 hours
20 hours - Observation period:
- 8 days
- Number of animals:
- 2 rabbits (5 minutes, 2 hours)
6 rabbits (20 hours) - Details on study design:
- TEST SITE
- Area of exposure: back (2.5 cm x 2.5 cm)
REMOVAL OF TEST SUBSTANCE
- Washing: yes
- Time after start of exposure: 24 hours
SCORING SYSTEM
OECD Draize scores.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Remarks:
- (20-hour exposure)
- Basis:
- mean
- Remarks:
- (animal #1)
- Time point:
- other: 24/48/72 hours
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Remarks on result:
- other: tested on intact skin
- Irritation parameter:
- erythema score
- Remarks:
- (20-hour exposure)
- Basis:
- mean
- Remarks:
- (animal #2)
- Time point:
- other: 24/48/72 hours
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Remarks on result:
- other: tested on intact skin
- Irritation parameter:
- erythema score
- Remarks:
- (20-hour exposure)
- Basis:
- mean
- Remarks:
- (animal #3)
- Time point:
- other: 24/48/72 hours
- Score:
- 1.5
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Remarks on result:
- other: tested on intact skin
- Irritation parameter:
- erythema score
- Remarks:
- (20-hour exposure)
- Basis:
- mean
- Remarks:
- (animal #4)
- Time point:
- other: 24/48/72 hours
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Remarks on result:
- other: tested on intact skin
- Irritation parameter:
- erythema score
- Remarks:
- (20-hour exposure)
- Basis:
- mean
- Remarks:
- (animal #5)
- Time point:
- other: 24/48/72 hours
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Remarks on result:
- other: tested on intact skin
- Irritation parameter:
- erythema score
- Remarks:
- (20-hour exposure)
- Basis:
- mean
- Remarks:
- (animal #6)
- Time point:
- other: 24/48/72 hours
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 days
- Remarks on result:
- other: tested on intact skin
- Irritation parameter:
- edema score
- Remarks:
- (20-hour exposure)
- Basis:
- mean
- Remarks:
- (animal #1)
- Time point:
- other: 24/48/72 hours
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Remarks on result:
- other: tested on intact skin
- Irritation parameter:
- edema score
- Remarks:
- (20-hour exposure)
- Basis:
- mean
- Remarks:
- (animal #2)
- Time point:
- other: 24/48/72 hours
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Remarks on result:
- other: tested on intact skin
- Irritation parameter:
- edema score
- Remarks:
- (20-hour exposure)
- Basis:
- mean
- Remarks:
- (animal #3)
- Time point:
- other: 24/48/72 hours
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Remarks on result:
- other: tested on intact skin
- Irritation parameter:
- edema score
- Remarks:
- (20-hour exposure)
- Basis:
- mean
- Remarks:
- animal #4
- Time point:
- other: 24/48/72 hours
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Remarks on result:
- other: tested on intact skin
- Irritation parameter:
- edema score
- Remarks:
- (20-hour exposure)
- Basis:
- mean
- Remarks:
- (animal #5)
- Time point:
- other: 24/48/72 hours
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Remarks on result:
- other: tested on intact skin
- Irritation parameter:
- edema score
- Remarks:
- (20-hour exposure)
- Basis:
- mean
- Remarks:
- (animal #6)
- Time point:
- other: 24/48/72 hours
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Remarks on result:
- other: tested on intact skin
- Irritant / corrosive response data:
- Test on intact skin, 20-hour application (key information):
The key results are summarised in the irritation/corrosion results table (see above).
The mean erythema score (24/48/72 hours) for the 6 rabbits ranged from 1 to 2. Findings were fully reversibe in 5/6 rabbits within 72 hours and in 1/6 rabbits within the observation period of 8 days.
The mean edema score (24/48/72 hours) for the 6 rabbits was 1. Findings were fully reversible within 72 hours.
Test on abraded (scarified) skin, 20- or 24-hour application (supporting information):
The mean erythema score (24/48/72 hours) for the 6 rabbits was 2.8. The erythema seen in all animals were not reversible within the 8-day observation period. On day 8, necroses indicative of strong irritancy were seen in 4/6 rabbits and scaling was noted in the 2 remaining rabbits.
The mean edema score (24/48/72 hours) for the 6 rabbits was 2.0. Edema were fully reversible in 5/6 rabbits within 8 days, while the edema score for the remaining rabbit was 2 on day 8.
Short-term test (supporting information):
No findings were noted in 2/2 rabbits (24/48 hours and 8 days) following exposure for 5 min. Exposure for 2 hours resulted in a mean erythema score of 0.5 (score 1 at 24 hours, score 0 at 48 hours) and no edema in both rabbits. The findings were fully reversible within 48 hours. - Other effects:
- Macroscopic examination revelaed yellow discolouration of fat tissue in one rabbit and the presence of parasites in the liver of another rabbit. The local clinical findings noted during the in-life period (necrosis, scaling) were confirmed for all animals.
Any other information on results incl. tables
A primary irritation score of 3.53 was calculated (under consideration of the test results for intact plus abraded skin). The test substance was considered to be a moderate irritant based on this score.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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