Registration Dossier
Registration Dossier
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EC number: 500-071-2 | CAS number: 30599-15-6 1 - 8.5 moles ethoxylated
Endpoint summary
Administrative data
Description of key information
Additional information
Read-across statement
No-Longer-Polymer (NLP) polyether polyols are produced by the reaction of various starter molecules with propylene oxide and/or ethylene oxide. These substances exhibit a remarkable uniformity in the physical/chemical properties which influence their fate and distribution in the environment. All NLP polyols have a full acute aquatic ecotoxicity dataset and do not exhibit acute toxicity below 100 mg/L. However, differentiation in chronic invertebrate toxicity is apparent and is based on the alcohol- or amino- starter molecules used to prepare these NLP polyols. A sub-grouping based on (i) aliphatic alcohol and amine NLP polyols, (ii) EDA- (ethylenediamine) based amino NLP polyols and (iii)o-TDA-(orthodiaminotoluene) based aromatic NLP polyols is justified (ISOPA, 2010) and toxicity is expected to be similar between substances within each of these categories. It is considered appropriate to use ‘read-across’ of data of structural analogues within each sub-grouping to fill data gaps for chronic invertebrate toxicity and derive PNECs for endpoints based on these sub-groupings.
All tests were performed using structurally comparable substance. On the one hand, tests from the analogous substance D-Glucitol propoxylated (CAS# 52625-13-5) was applied, on the other hand test were performed using Pentaerythritol propoxylated (CAS# 9051-49-4). Both substances are structurally comparable to Pentaerythritol ethoxylated. The core molecules D-Glucitol and Pentaerythritol are comparable substances. Their multiple hydroxy groups which are attached to a branched or linear alkyl chain are propoxylated to a known amount. Ethoxylated and propoxylated side chains of the same length as given here are supposed to have the same environmental and toxicological profile. Hence, read across in the no-longer polymer category is considered valid.
96 hr LC50 (Danio rerio) > 100 mg/l. (no effects observed on CAS# 9051-49-4).
48 hr EC50 (Daphnia magna) >100 mg/l (nominal), for CAS# 9051-49-4.
The 21d-NOEC to Daphnia magna with the structurally related substance D-Glucitol (Sorbitol), propoxylated (CAS# 52625-13-5) in a OECD 211 guideline study is ≥ 10 mg/l (nominal) for all endpoints.
Toxicity to algae and cyanobacteria has been tested on D-Glucitol (Sorbitol), propoxylated (CAS# 52625-13-5) using
Desmodesmus subspicatus over a 72 hr period at 100 mgl/l. No effects were observed and the EC0 (biomass and growth rate) are >=100 mgl/l.
3 hr EC10 respiration inhibition (activated sludge) > 10,000 mg/l (nominal). No inhibition was observed for CAS# 9051-49-4.
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