Aluminium triisopropanolate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1969

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Limited documentation on the study, however, basic information is given. From the available information, similar procedure to acute oral toxicity guideline followed.

Data source

Reference

Reference Type:

publication

Title:

Range-Finding toxicity data: List VII

Author:

Smyth, H.F., Carpenter, C.P., Weil, C.S., Pozzani, U.C., Striegel, J.A., Nycum J.S.

Year:

1969

Bibliographic source:

Am. Ind. Hyg. Assoc. J., 1969, 30:5, 470-476

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Aluminum isopropylate

IUPAC Name:

Aluminum isopropylate

Constituent 2

Reference substance name:

Aluminium triisopropanolate

EC Number:

209-090-8

EC Name:

Aluminium triisopropanolate

Cas Number:

555-31-7

Molecular formula:

C3H8O.1/3Al

IUPAC Name:

aluminium triisopropanolate

Test material form:

not specified

Details on test material:

No further information on the test material is available.

Test animals

Species:

rat

Strain:

other: Carworth-Wistar

Sex:

male

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: inhouse
- Age at study initiation: 4-5 weeks
- Weight at study initiation: 90-120g
- Fasting period before study: not fasted
- Diet: Rockland rat diet

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

other: suspended in 0.25% agar

Doses:

Logarithmic series, differing by a factor of 2

No. of animals per sex per dose:

5 animals per dose

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days

Statistics:

LD50 and fiducial range estimated by the method described by Thomson (Thomson, W.R., Bacteriol. Rev., 1947, 11, 115) and Weil (Weil, C.S., Biometrics, 1952, 8, 249).

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

11 300 mg/kg bw

Based on:

test mat.

95% CL:

7 000 - 18 300

Remarks on result:

other: concentration intubated 0.2 g/ml

Any other information on results incl. tables

Confidence interval reported 7 - 18.3 g/kg bw.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The oral acute toxicity reported as LD50 in this study was found to be 11.3 g/kg bw (i.e. 11'300 mg/kg bw)

Executive summary:

The work of this group pre-dates range finding toxicity guidelines and provided much of the basis for their development. Their results are cited by many subsequent authoritative review bodies and are often found in SIDS and SIAR documents via secondary references. Therefore, these results (LD50 (oral, rat) = 11300 mg/kg bw) are deemed reliable.