Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 404-290-3 | CAS number: 7216-95-7
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The toxicity of DTPA to microorganisms was assessed in several studies, including an OECD 209 activated sludge respiration inhibition test, and several biodegradation screening tests. In the activated sludge respiration inhibition study the 3-hour EC50 was greater than 1480 mg/L.
Key value for chemical safety assessment
Additional information
In an OECD 209 test, a 3 -hour EC50 value could not be determined for DTPA acid, with only 23% inhibition observed at 1000 mg/L (1480 mg/L pentapotassium DTPA), the highest concentration tested. In an OECD 302B inherent biodegradation test, no inhibition of activated sludge inoculum was observed at 100 mg/L DTPA acid (148 mg/L pentapotassium DTPA). In batch biodegradation studies using microbial inocula from pulp mill activated sludge, municipal activated sludge, and soil, no microbial inhibition was reported for DTPA acid concentrations of 400 mg/L (593 mg/L pentapotassium DTPA). Using pulp mill activated sludge pre-exposed to DTPA, no inhibition was reported in reaction mixtures containing 725 mg/L DTPA acid (1075 mg/L pentapotassium DTPA). These results are consistent with the structurally similar compound EDTA, where EDTA did not significantly inhibit the respiration of activated sludge in an OECD 209 test up to a nominal concentration of 500 mg/L (EC20, EC50, EC80 >500 mg/L).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
