Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
skin irritation / corrosion
Remarks:
in vitro
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1978

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Methylphosphonous dichloride
EC Number:
211-631-8
EC Name:
Methylphosphonous dichloride
Cas Number:
676-83-5
Molecular formula:
CH3Cl2P
IUPAC Name:
methylphosphonous dichloride

Test animals

Species:
rabbit
Strain:
Himalayan

Test system

Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
other: sesame oil
Controls:
not specified
Duration of treatment / exposure:
24 h
Observation period:
72 h
Number of animals:
6

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 24-72 h
Score:
1.5
Max. score:
2
Reversibility:
no data
Remarks:
application site dicoloured; skin cracked
Remarks on result:
other: 10% solution in vehicle
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 24-72 h
Score:
2.44
Max. score:
4
Reversibility:
no data
Remarks on result:
other: 10% solution in vehicle
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 24-72 h
Score:
0.72
Max. score:
1
Reversibility:
no data
Remarks on result:
other: 1% solution in vehicle
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 24-72 h
Score:
0.5
Max. score:
1
Reversibility:
no data
Remarks on result:
other: 1% solution in vehicle

Applicant's summary and conclusion

Interpretation of results:
corrosive
Remarks:
Migrated information Criteria used for interpretation of results: EU