Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 403-700-8 | CAS number: 2687-94-7 NOP; SURFADONE LP-100 SURFACTANT
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- other: A theoretical summary of the toxicokinetics is provided in the attachments.
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The argument covers on the theoretical details, and is not an experimental study.
Data source
Reference
- Reference Type:
- other: An argument written internally
- Title:
- Unnamed
- Year:
- 2 012
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- No guideline has been followed, as this is a theoretical argument.
- GLP compliance:
- not specified
- Remarks:
- Not relevant - data is a theoretical argument
Test material
- Reference substance name:
- N-(n-octyl)-2-pyrrolidinone
- EC Number:
- 403-700-8
- EC Name:
- N-(n-octyl)-2-pyrrolidinone
- Cas Number:
- 2687-94-7
- Molecular formula:
- C12H23NO
- IUPAC Name:
- N-(n-octyl)-2-pyrrolidinone
- Details on test material:
- Not relevant for a theoretical argument
Constituent 1
- Radiolabelling:
- not specified
- Remarks:
- Not relevant for a theoretical argument
Administration / exposure
- Route of administration:
- other: Not relevant for a theoretical argument
- Vehicle:
- other: Not relevant for a theoretical argument
- Details on exposure:
- Not relevant for a theoretical argument
- Duration and frequency of treatment / exposure:
- Not relevant for a theoretical argument
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Not relevant for a theoretical argument
- No. of animals per sex per dose / concentration:
- Not relevant for a theoretical argument
- Control animals:
- other: Not relevant for a theoretical argument
- Positive control reference chemical:
- Not relevant for a theoretical argument
- Details on study design:
- Not relevant for a theoretical argument
- Details on dosing and sampling:
- Not relevant for a theoretical argument
- Statistics:
- Not relevant for a theoretical argument
Results and discussion
- Preliminary studies:
- Not relevant for a theoretical argument
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Not relevant for a theoretical argument
- Details on distribution in tissues:
- Not relevant for a theoretical argument
- Details on excretion:
- Not relevant for a theoretical argument
Metabolite characterisation studies
- Details on metabolites:
- Not relevant for a theoretical argument
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): low bioaccumulation potential based on study results
N-(n-octyl)-2-pyrrolidinone will only slightly bioaccumulate. - Executive summary:
A theoretical argument is provided, and this shows that bioaccumulation should be low.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
