Registration Dossier
Registration Dossier
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EC number: 403-700-8 | CAS number: 2687-94-7 NOP; SURFADONE LP-100 SURFACTANT
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- other: A theoretical summary of the toxicokinetics is provided in the attachments.
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The argument covers on the theoretical details, and is not an experimental study.
Data source
Reference
- Reference Type:
- other: An argument written internally
- Title:
- Unnamed
- Year:
- 2 012
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- No guideline has been followed, as this is a theoretical argument.
- GLP compliance:
- not specified
- Remarks:
- Not relevant - data is a theoretical argument
Test material
- Reference substance name:
- N-(n-octyl)-2-pyrrolidinone
- EC Number:
- 403-700-8
- EC Name:
- N-(n-octyl)-2-pyrrolidinone
- Cas Number:
- 2687-94-7
- Molecular formula:
- C12H23NO
- IUPAC Name:
- N-(n-octyl)-2-pyrrolidinone
- Details on test material:
- Not relevant for a theoretical argument
Constituent 1
- Radiolabelling:
- not specified
- Remarks:
- Not relevant for a theoretical argument
Administration / exposure
- Route of administration:
- other: Not relevant for a theoretical argument
- Vehicle:
- other: Not relevant for a theoretical argument
- Details on exposure:
- Not relevant for a theoretical argument
- Duration and frequency of treatment / exposure:
- Not relevant for a theoretical argument
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Not relevant for a theoretical argument
- No. of animals per sex per dose / concentration:
- Not relevant for a theoretical argument
- Control animals:
- other: Not relevant for a theoretical argument
- Positive control reference chemical:
- Not relevant for a theoretical argument
- Details on study design:
- Not relevant for a theoretical argument
- Details on dosing and sampling:
- Not relevant for a theoretical argument
- Statistics:
- Not relevant for a theoretical argument
Results and discussion
- Preliminary studies:
- Not relevant for a theoretical argument
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Not relevant for a theoretical argument
- Details on distribution in tissues:
- Not relevant for a theoretical argument
- Details on excretion:
- Not relevant for a theoretical argument
Metabolite characterisation studies
- Details on metabolites:
- Not relevant for a theoretical argument
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): low bioaccumulation potential based on study results
N-(n-octyl)-2-pyrrolidinone will only slightly bioaccumulate. - Executive summary:
A theoretical argument is provided, and this shows that bioaccumulation should be low.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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