Registration Dossier
Registration Dossier
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EC number: 403-700-8 | CAS number: 2687-94-7 NOP; SURFADONE LP-100 SURFACTANT
Endpoint summary
Administrative data
Description of key information
N-(n-octyl)-2-pyrrolidinone has been found to be corrosive to skin and severely irritating to eyes. It is classified as R34/H314.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
The eye irritation study provided by ECHA in the migrated NONS file demonstrates that N-(n-octyl)-2 -pyrrolidinone is found to be irritating to eyes and should be classified with the R41 risk phrase or H318 hazard phrase.
Four skin irritation/corrosion studies have been provided by ECHA in the migrated NONS file. These all show that N-(n-octyl)-2 -pyrrolidinone is corrosive and should be classified with the R34 risk phrase or H314 hazard phrase.
N-(n-octyl)-2 -pyrrolidinone is classified as Skin Corr. 1b, or R34: Corrosive.
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: highly irritating
Justification for classification or non-classification
In the eye irritation study the maximum score for chemosis was 3.17, cornea opacity 1.33 and iris lesion 0.83. The damage to the eye persisted to the end of the test. Due to the irreversibility of the effects N-(n-octyl)-2-pyrrolidinone should be classified as R41 risk of serious damage to eyes or H318 causes serious eye damage (Eye Damage 1).
In the skin irritation studies N-(n-octyl)-2-pyrrolidinone was found to be corrosive and should be labelled R34 causes burns or H314 causes severe skin burns and eye damage.
Due to the labelling of R34/H314, R41/H318 is not necessary since this is implicit in the classification.
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