6-methylhept-5-en-2-one

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Acceptable, well documented study report which meets basic scientific principles

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

other company data

Title:

Unnamed

Year:

1974

Report date:

1974

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Study was performed acc. internal BASF method.
The inhalation hazard test was performed. The aim of the test was to demonstrate the toxicity of an atmosphere saturated with vapours of the volatile components of the test substance at a temperature chosen for vapour generation (i.e. 20 °C for the present test substance). The animals were exposed to the test substance for 8 hours.

GLP compliance:

no

Test type:

standard acute method

Test material

Test material information

Constituent 1

Reference substance name:

6-methylhept-5-en-2-one

EC Number:

203-816-7

EC Name:

6-methylhept-5-en-2-one

Cas Number:

110-93-0

Molecular formula:

C8H14O

IUPAC Name:

6-methylhept-5-en-2-one

Details on test material:

- Name of test material (as cited in study report): 6-Methyl-5-hepten-2-one
- Analytical purity: 98 %

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: average 167 g

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

other: air

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- System of generating particulates/aerosols: generated by bubbling 200 l/h air through a substance column of about 5 cm above a fritted glass disc in a glass cylinder for different time periods (8 hours)

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

8 h

Concentrations:

6.98 mg/l (6980 mg/m3) was calculated by using the weight loss of test substance and the amount of air used during exposure.

No. of animals per sex per dose:

12 animals were used

Control animals:

no

Details on study design:

- Duration of observation period following administration: 7 days
- Frequency of weighing: before the start of the study and at the end of the observation period in the surviving animals
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Results and discussion

Mortality:

No mortality observed

Clinical signs:

other: Immediately after exposure, the animals showed impaired balance. The next day, all animals were normal again.

Gross pathology:

no abnormal effects detected

Any other information on results incl. tables

A LC50 of > 13.96 mg/l/4 hrs can be estimated  using 
Haber's rule, LC50 > 6.98 mg/l/8 hrs. However, determination of the test substance
concentration was not performed according to current standarts.