Registration Dossier
Registration Dossier
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EC number: 256-367-4 | CAS number: 49553-76-6
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The chemical safety assessment according to Annex I of Regulation (EC) No. 1907/2006 does not indicate the need to investigate further the long-term toxicity to fish.
Key value for chemical safety assessment
Additional information
No experimental data on long-term toxicity to fish are available for Oleic acid, monoester with oxybis(propandiol) (CAS 49553-76-6). The chemical safety assessment according to Annex I of Regulation (EC) 1907/2006 does not indicate the need to investigate further the long-term toxicity to fish. Based on the short-term fish results from a structurally related read-across substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5), it can be concluded that Oleic acid, monoester with oxybis(propandiol) will not exhibit short-term effects to fish up to the limit of water solubility. Effects were observed for short-term daphnia (EC50 (48h) = 37.5 mg/L) as well as for toxicity to algae (NOEC (72h) = 0.0113 mg/L) for Oleic acid, monoester with oxybis(propandiol). Therefore, fish is the species showing the least sensitivity. Due to the existence of chronic values for both aquatic invertebrates (on a structurally related analogue substance, 2,3-dihydroxypropyl oleate, according to Regulation (EC) No. 1907/2006, Annex XI, 1.5) and algae, and the higher sensitivity of these organisms compared to that of fish, additional chronic toxicity data on fish is not deemed necessary.
Moreover, in accordance with Annex IX, column 2 of Regulation (EC) No 1907/2006, long-term toxicity testing to fish does not need to be conducted as the Chemical Safety Assessment does not indicate a need for further investigations. The environmental exposure assessment for methyl decanoate according to Annex XI, Section 3 indicates no risk for the aquatic compartment (all RCR < 1; please refer to Chapter 9 and 10 of the Chemical Safety Report for detailed information). Thus, a long-term test with fish is not deemed necessary.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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