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EC number: 213-192-8 | CAS number: 928-96-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2 August to 9 August 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards with acceptable restrictions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: U.S. Federal Register Test (1964)
- Deviations:
- no
- Principles of method if other than guideline:
- The rabbit was securely restrained by a technician. The left side of the shaved dorsum was abraded by drawing the tip of a lancet across the skin forming a lattice pattern with parallel abrasions at intervals of 5- 10 mm. The abrasions were such as the break the stratum corneum of the epidermis without damaging the underlying tissues or causing bleeding. The right of the shaved site was left intact.
- GLP compliance:
- no
- Remarks:
- Study predates GLP.
Test material
- Reference substance name:
- cis-hex-3-en-1-ol
- EC Number:
- 213-192-8
- EC Name:
- cis-hex-3-en-1-ol
- Cas Number:
- 928-96-1
- Molecular formula:
- C6H12O
- IUPAC Name:
- hex-3-en-1-ol
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study report): cis-3-hexen-1-ol
- Physical state: colourless liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Morton Commercial Rabbits, Parsonage Farm, Stansted, Essex, England
- Age at study initiation: 2.5- 3 months
- Weight at study initiation: 2.2- 3.3 kg
- Housing: animals were individually housed in suspended galvanised and stainless steel cages in batteries manufactured by Cope & Cope Limited. The cages measured 0.6 x 0.6 x 0.4 m high and were fitted with mesh floors and automatic watering. A sledge running the length if the battery removed waste matter from an undertray beneath the cage floors, as required.
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 14 d
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 15 °C ± 2 °C
- Humidity (%): 50 % ± 10 %
- Air changes (per hr): 17
- Photoperiod (hrs dark / hrs light): 14/ 10
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 mL of test material was impregnated onto unmedicated gauze patches (25 x 25 mm) and were applied, 1 patch to each side of the abraded and intact treatment areas.
- Duration of treatment / exposure:
- 23 h
- Observation period:
- 24 h, 72 h and 7 d
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Type of wrap if used: patches were covered by slightly larger sheets of aluminium foil, and were kept in place by an impermeable bandage of a plastic self-adhesive dressing which was wrapped twice around the trunk of the rabbit with sufficient tension to ensure the test material was in close contact to the skin.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): excess test material was removed by gently washing with warm water ans drying the site with paper towels.
- Time after start of exposure: 23 h
SCORING SYSTEM: reactions of the intact and abraded test sites were assessed according to the criteria of Draize.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- Animal 1
- Time point:
- other: 24 h, 72 h
- Score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- animal 2
- Time point:
- other: 24 h, 72 h
- Score:
- 0.5
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- animal 3
- Time point:
- other: 24 h, 72 h
- Score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- animal 4
- Time point:
- other: 24 h, 72 h
- Score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- animal 5
- Time point:
- other: 24 h, 72 h
- Score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- animal 6
- Time point:
- other: 24 h, 72 h
- Score:
- 0.5
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- animal 1
- Time point:
- other: 24 h, 72 h
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- animal 2
- Time point:
- other: 24 h, 72 h
- Score:
- 0.5
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- animal 3
- Time point:
- other: 24 h, 72 h
- Score:
- 0.5
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- animal 4
- Time point:
- other: 24 h, 72 h
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- animal 5
- Time point:
- other: 24 h, 72 h
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- animal 6
- Time point:
- other: 24 h, 72 h
- Score:
- 0.5
- Irritant / corrosive response data:
- Upon single dermal application of the test material, barely perceptible and/or well-defined erythematous responses were provoked on intact and/or abraded skin in 3 animals at 24 h. Four animals displayed slight oedematous responses on intact and/or abraded skin at the 24-h reading. The responses diminished in intensity so that, by 72 h, 2 animals displayed barely perceptible erythematous responses and 1 very slight oedematous response. One animal displayed discolouration of the abraded skin at 24 and 72 h. All animals displayed loss of pliability of intact and abraded skin. On Day 8 one animal displayed severe erythema with loss of flexibility and discolouration of intact and abraded skin; 1 animal displayed moderate to severe erythema to severe erythema and exfoliation on intact and abraded skin and 2 animals displayed exfoliation on intact and abraded skin.
Any other information on results incl. tables
Scoring of irritance responses elicited by single dermal application of 0.5 mL of test material under a 24 -h occlusive bandage
Animal number & sex |
Type of response |
Score at 24 hours |
Score at 72 hours |
Overall score |
Score at Day 7 |
|||
Intact skin |
Abraded skin |
Intact skin |
Abraded skin |
Intact skin |
Abraded skin |
|||
3TA 155 ♂ |
Erythema |
0 |
2+ |
0* |
0* |
1.00 |
4+α |
4+α |
Oedema |
0 |
2 |
0 |
0 |
0 |
0 |
||
3TA 157 ♂ |
Erythema |
0 |
0 |
1* |
1* |
1.00 |
0* |
0* |
Oedema |
1 |
1 |
0 |
0 |
0 |
0 |
||
3TA 158 ♂ |
Erythema |
0 |
2 |
0* |
1* |
1.50 |
0 |
0* |
Oedema |
0 |
1 |
1 |
1 |
0 |
0 |
||
3TA 159 ♂ |
Erythema |
0 |
0 |
0* |
0* |
0 |
0ε |
0ε |
Oedema |
0 |
0 |
0 |
0 |
0 |
0 |
||
3TA 160 ♂ |
Erythema |
0 |
0 |
0* |
0* |
0.25 |
0ε |
0ε |
Oedema |
0 |
1 |
0 |
0 |
0 |
0 |
||
3TA 161 ♂ |
Erythema |
1 |
1 |
0+* |
0+* |
1.00 |
3ε |
3ε |
Oedema |
1 |
1 |
0 |
0 |
0 |
0 |
+- Discolouration
*- Loss of pliability
ε- Exfoliation
α- Loss of flexibiility
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP criteria not met
- Conclusions:
- The test material was assessed for irritance responses during a single application of the test material on the intact and abraded skin of the dorsum of rabbits. The test substance is not considered to be irritating to skin according to the classification criteria of CLP Regulation (EC) no. 1272/2008
- Executive summary:
The test material was assessed for irritance responses during a single application of the test material on the intact and abraded skin of the dorsum of rabbits. 0.5 mL of test material was impregnated onto unmedicated gauze patches and were applied, 1 patch to each side of the abraded and intact treatment areas. Upon single dermal application of the test material, barely perceptible and/or well-defined erythematous responses were provoked on intact and/or abraded skin in 3 animals at 24 h. Four animals displayed slight oedematous responses on intact and/or abraded skin at the 24-h reading. The responses diminished in intensity so that, by 72 h, 2 animals displayed barely perceptible erythematous responses and 1 very slight oedematous response. One animal displayed discolouration of the abraded skin at 24 and 72 h. All animals displayed loss of pliability of intact and abraded skin. On Day 8 one animal displayed severe erythema with loss of flexibility and discolouration of intact and abraded skin; 1 animal displayed moderate to severe erythema to severe erythema and exfoliation on intact and abraded skin and 2 animals displayed exfoliation on intact and abraded skin. Under the conditions of this study the test substance is not considered to be irritating to skin.
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