Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-350-6 | CAS number: 57-83-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
In humans, progesterone is converted by reduction, hydroxylation, side-chain cleavage and conjugation. Qualitative (Aufrère & Benson, 1976) and quantitative (Little et al, 1975) species differences have been observed. In humans, most progesterone is metabolized by reductases, the main product being pregnanediol (5b-pregnane-3a,20a-diol), excreted as the glucuronide. In chimpanzees, progesterone is metabolized similarily, and pregnanediol is the major excretion product (YoungLai et al., 1975); some human primates, such as baboons and rhesus monkeys, excrete androsterone as the major urinary product, implying that in these species side-chain cleavage predominates (Aufrère & Benson, 1976; Isihara et al, 1975). Some species excrete acidic progesterone metabolites, i.e. metabolites that arise from hydroxylation at C-21 and further oxidation to the C-21 -carboxyl derivative in the urine (Senciall & Dey, 1976). Rabbits excrete the largest amounts of this type of metabolite, followed by guinea-pigs, pigs and rats. Only negligable amounts are found in human urine (Senciall et al, 1976). Extrahepatic metabolism of progesterone also occurs to an appreciable extent. In rats, for instance, submaxillary gland tissue has been shown to contain 5a-reductase, 20a-reductase and 17a-hydroxylase (Coffey, 1973). Circulating progesterone can be utilized by the adrenals for the production of corticosteroids like aldosterone and corticosterone, as demonstrated by Vecsei & Kessler (1971) in rats.
References
Aufrère, M.B. & Benson, H. (1976) Progesterone: an overview and recent advances. J. pharm. Sci. 65, 783-800.
Coffey, J.C. (1973) In vitro progesterone metabolism in rat submaxillary gland: the formation of 20a-hydoxy-4-pregnen-3-one and other substances. Steroids 22, 561-566.
Ishihara, M., Osawa, Y., Kirdani, R.Y. & Sandberg, A.A. (1975) Progesterone metabolism in the baboon. J. Steroid Biochem. 6, 1213-1218.
Little, B., Billiar, R.B., Rahman, S.S., Johnson, W.A., Takaoka, Y. & White, R.J. (1975) IN vivo aspects of progesterone distribution and metabolism. Am. J. Obstet. Gynecol. 123, 527-534.
Senciall, I.R. & Dey, A.C. (1976) Acidic steroid metabolits: evidence for the excretion of C-21-carboxylic acid metabolites of progesterone in rabbit urine. J. Steroid Biochem. 7, 125-129.
Senciall, I.R., Harding, C.A. &Dey, A.C. (1976) Acidic steroid metabolites: species differences in the urinary excretion of acidic metabolites of progesterone. J. Endocrinol. 68, 169-170.
Vecsei, P & Kessler, H. (1971) In vivo conversion of radioactive progesterone and corticosterone to adrenal cortical hormones in normal and ACTH-treated rats. Acta endocrinol.68, 759-770.
YoungLai, E.V., Graham, C.E. & Collins, D.C. (1975) Metabolism of 4-14C-progesterone in the adult female chimpanzee. Steroids, 25, 465-476.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.