Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 211-519-9 | CAS number: 657-27-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Guidance on Safe Use
Administrative data
First-aid measures
Inhalation : In case of breathing trouble, immediately relocate to a fresh air environment. Rinse mouth with water. If not breathing, give artificial respiration. If breathing becomes difficult give oxygen and seek medical attention.
Eye contact : Flush eyes with copious amounts of water for at least 15 minutes. Ensure adequate flushing by separating eyelids with fingers. If contact lenses are worn, remove lenses and continue rinsing. Seek medical attention.
Skin contact : In case of exposure, wash with soap and copious amounts of water. If irritation persists, seek medical attention.
Ingestion : Rinse mouth with water. If any trouble appears, seek medical attention.
Fire-fighting measures
Extinguishing Method : Water spray, carbon dioxide, dry chemical powder/foam
Fire and explosion hazards : Avoid electric and electrostatic sparks
Protective measures : Wear protective clothing and breathing mask to protect from fumes
Accidental release measures
Personal precautions
Respiratory : It is recommended to wear a (paper) mask covering nose and mouth.
Hands : It is recommended to wear gloves, especially in case of extended contact (although ‘L-Lysine-monohydrochloride, technically pure’ is not considered as irritant/corrosive for skin.
Eyes : It is recommended to wear safety goggles (although ‘L-Lysine-monohydrochloride, technically pure’ is not considered to be irritant/corrosive for the eye.
Skin: It is recommended to wear protective clothes covering skin. Discard or wash protective clothes after exposition to dust of the product.
Environmental exposure controls: The amino acid L-lysine is a building block for protein(s) and a usual constituent of foods or feeds. Biodegradable. In case of release in large quantities, avoid releasing in sewers. When a large quantity of the product is released in a river or waste water treatment plant, the ecosystem or the functioning of the plant may be disturbed due to increased demand in oxygen required to degrade the product (increase of the biological oxygen demand – BOD – of water).
Methods for cleaning : Prevent spills from entering sewers and water courses. Avoid dust generation and ventilate the area. Wear mask.Collect the product and place it in bags or containers for later disposal and elimination as waste according to local legislation. After the material has been removed, rinse the spill site with water.
Handling and storage
Handling :
Follow good manufacturing practice and personal hygiene. Standard precautions for powdered products or products generating dust:
- Avoid dust dispersion during grinding or blending operations
- Provide mechanical exhaust or ventilation
- Clean and eliminate dust from equipments regularly
- Use anti-static equipment
- Avoid heat sources and sparks
Storage : In the bags in which the product has been delivered or in standard silos for bulk delivery. Keep in dry conditions. Keep away from ignition and heat sources.
This substance is handled under Strictly Controlled Conditions in accordance with REACH regulation Article 18(4). Site documentation to support safe handling arrangements including the selection of engineering, administrative and personal protective equipment controls in accordance with risk-based management systems is available at each Manufacturing site. Written confirmation of application of Strictly Controlled Conditions has been received from every affected Distributor and Downstream Manufacturer/User of the Registrant’s intermediate.
Transport information
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Marine transport (UN RTDG/IMDG)
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Additional transport information
Additional information
- Special provisions / remarks / other:
- Product packed in 25kg bags and 1 ton big-bags or carried in bulk.
Exposure controls / personal protection
Respiratory : It is recommended to wear a (paper) mask covering nose and mouth.
Hands : It is recommended to wear gloves, especially in case of extended contact (although ‘L-Lysine-monohydrochloride, technically pure’ is not considered as irritant/corrosive for skin.
This substance is handled under Strictly Controlled Conditions in accordance with REACH regulation Article 18(4). Site documentation to support safe handling arrangements including the selection of engineering, administrative and personal protective equipment controls in accordance with risk-based management systems is available at each Manufacturing site. Written confirmation of application of Strictly Controlled Conditions has been received from every affected Distributor and Downstream Manufacturer/User of the Registrant’s intermediate.
Eyes : It is recommended to wear safety goggles (although ‘L-Lysine-monohydrochloride, technically pure’ is not considered to be irritant/corrosive for the eye.
Skin: It is recommended to wear protective clothes covering skin. Discard or wash protective clothes after exposition to dust of the product.
Environmental exposure controls: None. Does not contain any substance subject to an exposure limit value. Amino acids are the building blocks of protein and are present in all living organisms : highly biodegradable.
Stability and reactivity
Stability : Stable if stored in dry conditions in sealed or closed containers
Conditions to avoid : Avoid electric and electrostatic sparks
Materials recommended for equipment : Stainless steel (INOX) 316 L
Hazardous decomposition products : When heated to decomposition chlorine and nitrous fumes will be emitted
Disposal considerations
Disposal according to local / national legislation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.