Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 231-810-4 | CAS number: 7747-35-5
Endpoint summary
Administrative data
Description of key information
Additional information
Based on a review of the ecotoxicity values from the acute fish, daphnid, and algal studies, the key studies indicated that EDHO exhibited acute toxicity (LC/EC50) values ranging from 1.08 to 244 mg/L. Freshwater green algae were the most sensitive of the three trophic levels to EDHO. The 72-hour ErC50 based on the growth rate endpoint was 1.08 mg/L and the NOEC was 0.513 mg /L.
A chronic 21-day reproduction test with Daphnia magna determined a NOEC of 5 mg/L.
EDHO is rapidly hydrolyzed to AEPD and formaldehyde, with half-lives of less than 4 hours at pH 4, 7, and 9 at 25 ºC. As a result of rapid hydrolysis and low potential for continuous input in the aquatic environment based on use patterns, potential for chronic exposure to EDHO is expected to be low. Bioaccumulation potential is expected to be minimal based on a reported log Kow of -0.32.
In addition, acute testing clearly indicated that fish were the least sensitive of the three trophic levels to EDHO exposure. The fish acute values ranged from 130 to 244 mg/L while the aquatic invertebrate acute values ranged from 16.9 to 138 mg/L and the algal acute values ranged from 1.08 to 2.09 mg/L. Chronic values were determined for algal species and the most sensitive invertebrate (Daphnia magna). The NOEC for the daphnid chronic study was determined to be 5 mg/L, an order of magnitude greater than the most sensitive trophic level (ErC50 for freshwater green alga of 0.513 mg/L. Since fish are vertebrates as well as the least acutely sensitive trophic level, it was neither scientifically nor ethically justified to determine a chronic value.
According to REACH Annex IX requirements, long-term toxicity testing shall only be considered when the chemical safety assessment indicates the need for further investigations. Hence, long-term testing can be waived for EDHO.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
