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EC number: 231-810-4 | CAS number: 7747-35-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was not conducted according to guideline/s and GLP but the report contains sufficient data to permit a meaningful evaluation of study results.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Deviations:
- not specified
- Remarks:
- No guideline listed
- Principles of method if other than guideline:
- P-1601 as supplied was administered by gavage as a single dose to COX-SD albino rats.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 7a-ethyldihydro-1H,3H,5H-oxazolo[3,4-c]oxazole
- EC Number:
- 231-810-4
- EC Name:
- 7a-ethyldihydro-1H,3H,5H-oxazolo[3,4-c]oxazole
- Cas Number:
- 7747-35-5
- Molecular formula:
- C7H13NO2
- IUPAC Name:
- 7a-ethyl-tetrahydro-1H-[1,3]oxazolo[3,4-c][1,3]oxazole
- Details on test material:
- - Name of test material (as cited in study report): P-1601 (Oxazolidine E, BIOBANTMCS-1246 Antimicrobial)
- Physical state: Light yellow colored liquid
- Analytical purity: 94.52%
- Lot/batch No.: M4590
- Stability under test conditions: Not reported assumed to be stable under normal storage conditions
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Not reported
- Age at study initiation: Age was not reported
- Weight at study initiation: 211±13 g
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: sterile deionized water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 0, 840, 1000, 1000, and 1000 mg/ml Respective to 0, 2100, 3000, 4200 and 6000 mg/kg
- Justification for choice of vehicle: Sterile Deionized Water
MAXIMUM DOSE VOLUME APPLIED:
1.5, 0.48-0.57, 0.60-0.7, 0.80-0.97 and 1.2-1.3 mL
(Set dosing volumes were not utilized)
Respective to
0, 2100, 3000, 4200 and 6000 mg/kg - Doses:
- 0, 2100, 3000, 4200, 6000 mg/kg/day
- No. of animals per sex per dose:
- 10
- Control animals:
- yes
- Details on study design:
- The test material was administered as a solution in sterilized deionized water by gavage as a single dose to 10 rats/sex/dose. The dose volume was varied based on the body weights of the Cox-SD rats used in the study.
Animals were observed frequently on the day of dosing, and daily thereafter for 14 days. Any unusual signs of toxicity or death were noted. Animals were subjected to a gross pathological examination as soon as possible after spontaneous death, or at the scheduled necropsy on day 14. - Statistics:
- The LD50 values with 95% confidence limits, and the slope were calculated according to Finney's probit analysis.
Results and discussion
- Preliminary study:
- At high doses of 6000 mg/kg/day, most males and all females died within 4 hours. The females were ataxic before death.
At 4200 mg/kg/day, most of the females and 2 males died within 4 hours. Necropsy showed distended stomachs. The male survivors at 4200 mg/kg and some of the females at 2100 mg/kg showed hemorrhagic nasal discharge. At necropsy, two male rats at 2100 mg/kg and two at 3000 mg/kg showed some lung infection. The organs in all other animals were grossly normal.
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 5 249 mg/kg bw
- Remarks on result:
- other: 4503-6673 mg/kg
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 3 674 mg/kg bw
- Remarks on result:
- other: 3216-4197 mg/kg
- Mortality:
- Mortality Data
Dose Mortality Mortality
(mg/kg) (males) (females)
0 0/10 0/10
2100 0/10 0/10
3000 0/10 1/10
4200 2/10 8/10
6000 7/10 10/10 - Clinical signs:
- other: At high doses of 6000 mg/kg/day, most males and all females died within 4 hours. The females were ataxic before death. At 4200 mg/kg/day, most of the females and 2 males died within 4 hours.
- Gross pathology:
- Necropsy showed distended stomachs. The male survivors at 4200 mg/kg and some of the females at 2100 mg/kg showed hemorrhagic nasal discharge. At necropsy, two male rats at 2100 mg/kg and two at 3000 mg/kg showed some lung infection. The organs in all other animals were grossly normal.
- Other findings:
- None
Any other information on results incl. tables
From the data the compound appers to be more toxic to female rats than to the male rats
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral LD50 of the material in male rats was reported to be 5249 mg/kg (4503-6673 mg/kg), and 3674 mg/kg (3216-4197 mg/kg) in females.
- Executive summary:
The test material was administered as a solution in sterilized deionized water by gavage as a single dose to 10 rats/sex/dose. The dose volume was varied based on the body weights of the Cox-SD rats used in the study.
Animals were observed frequently on the day of dosing, and daily thereafter for 14 days. Any unusual signs of toxicity or death were noted. Animals were subjected to a gross pathological examination as soon as possible after spontaneous death, or at the scheduled necropsy on day 14.
The LD50values with 95% confidence limits, and the slope were calucalted according to Finney's probit analysis.At high doses of 6000 mg/kg/day, most males and all females died within 4 hours. The females were ataxic before death.
At 4200 mg/kg/day, most of the females and 2 males died within 4 hours. Necropsy showed distended stomachs. The male survivors at 4200 mg/kg and some of the females at 2100 mg/kg showed hemorrhagic nasal discharge. At necropsy, two male rats at 2100 mg/kg and two at 3000 mg/kg showed some lung infection. The organs in all other animals were grossly normal.The acute oral LD50of the material in male rats was reported to be 5249 mg/kg (4503-6673 mg/kg), and 3674 mg/kg (3216-4197 mg/kg) in females.
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