Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (sensitising)
Additional information:

The ability of CS-1246 to induce dermal sensitization was examined in a Guinea Pig Maximization Test (Kreuzmann, J.J., 1989). Based on results of the induction/challenge CS-1246 was determined to be a dermal sensitizer in guinea pigs.



Kreuzmann, J.J. (1989) Guinea Pig Maximization Test (Magnusson and Kligman Method). Hill Top Biolabs. The Dow Chemical Company Report No: DR-0365-7725-005. GLP, Unpublished

Migrated from Short description of key information:
Based on a positive result in the guinea pig maximization study, the substance is expected to be a dermal sensitizer.

Justification for classification or non-classification

The substance is classified as Xi R43 (May cause sensitization by skin contact) according to DSD and as as a Skin sensitizer Cat.1; H317 (May cause an allergic reaction) according to CLP.