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EC number: 254-052-6 | CAS number: 38640-62-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 0 mg/L
- Assessment factor:
- 50
- Extrapolation method:
- assessment factor
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0 mg/L
- Assessment factor:
- 500
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 0.15 mg/L
- Assessment factor:
- 1
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 0.853 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 0.085 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 0.171 mg/kg soil dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- PNEC oral
- PNEC value:
- 25 mg/kg food
- Assessment factor:
- 68
Additional information
PNEC aqua (freshwater)
PNEC derivation following procedures of TGD (R.10):
For diisopropylnaphthalene, short-term toxicity tests have been performed for three trophic levels: fish, invertebrates (Daphnia magna), and green algae (Pseudokirchnerella subcapitata). In older studies, no relevant lethal or inhibitory effects were observed within the water solubility of DIPN. A recent study (Aniol et al 2012) demonstrated that acute toxic effects emerged under closed conditions of the test system with an effect loading EL50 of 1.7 mg/L.
Based on slight effects on the immobilization of daphnia within the water solubility of DIPN (EC0 = 0.066 mg/L), daphnia proved to be the most sensitive species. In tests using solubilising vehicles, daphnia also showed the lowest L/EC50 values.
For DIPN a long-term toxicity study with Daphnia is available (21 d reproduction test according to OECD 211). The determined NOEC was 0.0118 mg/L (meas. TWA). The result is confirmed by a second chronic toxicity study (21 d reproduction and immobilisation study according to OECD TG 202 part 2, adopted 1984) reporting a NOEC of 0.013 mg/L (nominal). In a 72-h growth inhibition test with green algae (Scenedesmus subspicatus), a 72-h NOEC of ca. 0.15 mg/L was determined (highest concentration tested, 80% of a saturated solution/water-accommodated fraction with a measured concentration of 0.19 mg/L).
Derivation of PNEC aqua freshwater can be based on results of long-term tests with organisms of two different trophic levels (Daphnia and algae). A test with the most sensitive species in short-term toxicity tests is included (Daphnia). The PNEC aqua freshwater will be calculated using the NOEC determined in this test (NOEC = 0.0118 mg/L) applying an assessment factor of 50 according to table R.10-4 in TGD "Guidance on information requirements and chemical safety assessment - Chapter R.10: Characterisation of dose[concentration]-response for environment".
PNEC aqua (marine water)
PNEC derivation following procedures TGD (R.10):
In addition to tests with freshwater, one study is available using the marine copepod Arcatia tonsa in a semi-static reproduction and mortality test with natural salt water. A NOEC of 0.02 mg/L was determined in this study.
As the long-term NOEC for daphnia is lower (0.0118 mg/L), the derivation of PNEC aqua (marine water) will be based on this value. With regard to a wider diversity of taxonomic groups in saltwater, an assessment factor of 500 will be used to allow for a broader distribution of sensitivities in the marine environment.
PNEC STP
In two growth inhibition tests using Pseudomonas putida and Tetrahymena pyriformis as test organisms, no toxicity was observed within the range of water solubility of diisopropylnaphthalene (EC10 > 0.16 mg/L, UBA/KBwS 1999a; EC0 > 0.15 mg/L, Yoshioka 1985). According to chapter R.10.4.2 and table R.10-6 in TGD "Guidance on information requirements and chemical safety assessment - Chapter R.10: Characterisation of dose[concentration]-response for environment", an assessment factor of 1 is applied to NOEC / EC10 values from growth inhibition tests withPseudomonas putida or Tetrahymena pyriformis.
PNEC sediment (freshwater)
According to chapter R10.5.2.1 of TGD "Guidance on information requirements and chemical safety assessment - Chapter R.10: Characterisation of dose[concentration]-response for environment",the PNEC sediment can provisionally be calculated in the absence of data for sediment-dwelling organisms using the equilibrium partitioning method (EPM).
PNEC derivation following procedures of TGD (R.10 and R.16):
PNEC water (freshwater): 0.000236 mg/L,
Koc: 36108 (EPA EPI Suite estimate, program KOCWIN v2.00, IUCLID sect. 5.4.1);
The PNEC sediment freshwater was calculated to 0.1854 mg/kg ww. This value was converted to dry weight (conversion factor of 4.6).
PNEC sediment (marine water)
According to chapter R10.5.3.1 of TGD "Guidance on information requirements and chemical safety assessment - Chapter R.10: Characterisation of dose[concentration]-response for environment", the PNEC sediment can provisionally be calculated in the absence of data for sediment-dwelling organisms using the equilibrium partitioning method (EPM).
PNEC derivation following procedures of TGD (R.10 and R.16):
PNEC water (marine water): 0.0000236 mg/L,
Koc: 36108 (EPA EPI Suite estimate, program KOCWIN v2.00, IUCLID sect. 5.4.1);
The PNEC sediment marine water was calculated to 0.01854 mg/kg ww. This value was converted to dry weight (conversion factor of 4.6).
PNEC soil
According to chapter R10.6.1 of TGD "Guidance on information requirements and chemical safety assessment - Chapter R.10: Characterisation of dose[concentration]-response for environment", the PNEC soil can provisionally be calculated in the absence of data for soil organisms using the equilibrium partitioning method (EPM).
PNEC derivation following procedures of TGD (R.10 and R.16):
PNEC water (freshwater): 0.000236 mg/L,
Koc: 36108 (EPA EPI Suite estimate, program KOCWIN v2.00, IUCLID sect. 5.4.1),
Vapour pressure: 1.422 Pa (OECD 104, IUCLID sect. 4.6)
Water solubility: 0.125 mg/L (EU Method A.6, IUCLID sect. 4.8)
Molecular weight: 212.33 g/mol
The PNEC soil was calculated to 0.1504 mg/kg ww. This value was converted to dry weight (conversion factor of 1.13).
Conclusion on classification
Diisopropylnaphthalene shows acute aquatic toxicity at loading range between 1 - 10 mg/L. Furthermore, the chronic toxicity is between 0.01 - 0.1 mg/L with a NOEC at 0.0118 mg/L. The latter triggers classification for chronic environmental hazards based on experimental evidence along with "non-rapid degradability", hence according to Regulation (EC) No 1272/2008 to be labelled with H410, Category Aquatic Chronic 1.
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