Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 254-052-6 | CAS number: 38640-62-9
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- short-term repeated dose toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only short abstract available
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
- Principles of method if other than guideline:
- Basic subacute 28 d repeated dose toxicity study with dermal administration of test substance
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Bis(isopropyl)naphthalene
- EC Number:
- 254-052-6
- EC Name:
- Bis(isopropyl)naphthalene
- Cas Number:
- 38640-62-9
- Molecular formula:
- C16H20
- IUPAC Name:
- bis(isopropyl)naphthalene
- Details on test material:
- - Name of test material (as cited in study report): R-300 (Diisopropylnaphthalene)
- no further information on test substance
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on exposure:
- Route of administration: dermal; test substance was applied on shaved skin of the back of rats (no further information)
- Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- 28 d
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
not specified
Basis:
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
Examinations
- Observations and examinations performed and frequency:
- CAGE SIDE OBSERVATIONS: No data
DETAILED CLINICAL OBSERVATIONS: No data
BODY WEIGHT: Yes
- Time schedule for examinations: daily
FOOD CONSUMPTION: Yes
- Time schedule for examinations: daily
FOOD EFFICIENCY: No data
WATER CONSUMPTION AND COMPOUND INTAKE (if drinking water study): No data
OPHTHALMOSCOPIC EXAMINATION: No data
HAEMATOLOGY: Yes
- Time schedule for collection of blood: before the start and at the end of the experiment
- Anaesthetic used for blood collection: No data
- Animals fasted: No data
- How many animals: No data
- Parameters examined: conventional hematological parameters
CLINICAL CHEMISTRY: Yes
- Time schedule for collection of blood: before the start and at the end of the experiment
- Animals fasted: No data
- How many animals: No data
- Parameters examined: total serum protein, blood urea nitrogen (BUN), serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), no further information
URINALYSIS: Yes
- Time schedule for collection of urine: before the start and at the end of the experiment
- Metabolism cages used for collection of urine: No data
- Animals fasted: No data
- Parameters examined: conventional urinary examination
NEUROBEHAVIOURAL EXAMINATION: No data - Sacrifice and pathology:
- GROSS PATHOLOGY: Yes, complete autopsy; various organ weights were determined.
HISTOPATHOLOGY: Yes
Results and discussion
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 385 mg/kg bw/day
- Sex:
- not specified
- Basis for effect level:
- other: no data
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- In a dermal 1 month repeated dose toxicity study, a NOAEL of 385 mg/kg bw/day was derived for DIPN under the test conditions used.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
