Sodium D-glycero-D-gulo-heptonate

Endpoint summary

Additional information

Three aquatic toxicity studies have been conducted according to GLP and OECD guidelines, these studies have been conducted on Oncorhynchus mykiss (rainbow trout), Daphnia magna (water flea) and Pseudokirchneriella subcapitata (green algae). All three studies were conducted on a closely related structural surrogate sodium glucoheptonate. For more details on our read across argument (please see section 13).

The results of the three short term aquatic tox satudies were as follows:

Fish LC50 = > 1000 mg/L; Fish NOEC = 1000 mg/L

Daphnia EC50 = > 1000 mg/L; Daphnia NOEC = 1000 mg/L

Algae EC50 = 790 mg/L Algae; NOEC = 100 mg/L

From the results of these three studies it can be seen that the algae is the most sensitive species to the test material. The algae study produced the lowest EC50 value out of all three aquatic toxicity studies, and all three studies were tested up to the same concentration level (1000 mg/L). The results of these studies were not sufficient to warrent classification as all EC/LC50 values are greater than the criteria for classification (<100 mg/l), plus the test material is readily biodegradale in water. Therefore the test material sodium d-glycero-d-gulo-heptonate has not been classified as hazardous to the environment.

An ASRI study was also conducted on the test material Sodium d-glycero-d-gulo-heptonate, the EC50 value was greater than 1000 mg/L and the NOEC was determined to be 1000 mg/L as no effects were observed within the study.