Registration Dossier
Registration Dossier
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EC number: 239-816-9 | CAS number: 15721-78-5
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Bis(4-(1,1,3,3-tetramethylbutyl) phenyl) amine attained 20% degradation after 28 days and therefore cannot be considered to be readily biodegradable, however the results indicate that the substance is inherently (primary) biodegradable (Harlan Laboratories, 2012).
Key value for chemical safety assessment
- Biodegradation in water:
- inherently biodegradable, not fulfilling specific criteria
Additional information
Key study:
In a study conducted according to OECD 301B (conducted to GLP), bis(4-(1,1,3,3-tetramethylbutyl) phenyl) amine attained 20% degradation after 28 days and therefore cannot be considered to be readily biodegradable under the strict conditions of the OECD Guideline (Harlan Laboratories, 2012). Bis(4-(1,1,3,3-tetramethylbutyl) phenyl) amine achieved 16% biodegradation by day 8, and reached 20% by day 14.
According to OECD TG 301, a substance can be considered Inherently Biodegradable where there is unequivocal evidence of biodegradation (primary or ultimate) in any test of biodegradability. According to the Introduction to the OECD Guidelines for Testing of Chemicals (Section 3) Part 1: Principles and Strategies Related to the Testing of Degradation of Organic Chemicals (July, 2003) Inherent Biodegradation rates above 20% may be regarded as evidence of inherent, primary biodegradability, whereas Inherent Biodegradation rates >70% may be regarded as evidence of inherent, ultimate biodegradability. The substances is considered a inherently biodegradable.
Supporting study:
Using The Estimation Programs Interface (EPI) SuiteTMwas developed by the US Environmental Protection Agency's Office of Pollution Prevention and Toxics and Syracuse Research Corporation (SRC), the ready biodegradation of bis(4-(1,1,3,3-tetramethylbutyl) phenyl) amine is determined as not readily biodegradable (EPIWIN, 2012).
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