Bis(4-(1,1,3,3-tetramethylbutyl)phenyl)amine

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Study period:

From 29 January to 12 February 1979

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Conducted in a similar manner to validated testing guidelines. Study pre-dates GLP.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1979

Report date:

1979

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Deviations:

no

Principles of method if other than guideline:

One group of ten (5 male and 5 female) albino rats was used in this study. The rats were placed in a 70 liter, all glass exposure chamber and exposed air for one hour. Following 14 days observation period during which time the rats were abserved for signs of toxicity and mortalities.

GLP compliance:

no

Test type:

acute toxic class method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Bis(4-(1,1,3,3-tetramethylbutyl)phenyl)amine

EC Number:

239-816-9

EC Name:

Bis(4-(1,1,3,3-tetramethylbutyl)phenyl)amine

Cas Number:

15721-78-5

Molecular formula:

C28H43N

IUPAC Name:

4-(2,4,4-trimethylpentan-2-yl)-N-[4-(2,4,4-trimethylpentan-2-yl)phenyl]aniline

Test material form:

solid: particulate/powder

Remarks:

migrated information: powder

Details on test material:

Batch No.: not specified.
Purity: not specified.

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Details on test animals or test system and environmental conditions:

None stated.

Administration / exposure

Route of administration:

inhalation: aerosol

Type of inhalation exposure:

whole body

Vehicle:

air

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE
- Exposure apparatus: Glass exposure chamber
- Exposure chamber volume: 70 liter
- Source and rate of air: The rate of flow was 10 liters per minute.
- Temperature, humidity, pressure in air chamber: 70 °F

VEHICLE
- Composition of vehicle (if applicable): Corn oil.
- Concentration of test material in vehicle (if applicable): 25% w/v

No additional data

Analytical verification of test atmosphere concentrations:

yes

Remarks:

Differential weighing

Duration of exposure:

1 h

Concentrations:

5.8 mg/litre during the exposure period. This is an average value over the one hour period.

No. of animals per sex per dose:

5 male and 5 female per dose.

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days.
- Frequency of observations and weighing: Observed once daily, weighed on initial day and final day.
- Necropsy of survivors performed: yes, Gross pathologic examination revealed nothing remarkable.
- Other examinations performed: Clinical signs, body weight.

Statistics:

None stated

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 5.8 mg/L air

Based on:

test mat.

Exp. duration:

1 h

Mortality:

No mortality were observed.

Clinical signs:

other: There were no unusual behavioral signs noted.

Body weight:

All animals gained normal body weight gain.

Gross pathology:

Gross pathologic examination revealed nothing remarkable.

Other findings:

No information provided.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

Bis(4-(1,1,3,3-tetramethylbutyl)phenyl)amine has an inhalation LC50 greater than 5.8 mg/L.